Norepinephrine Metabolism in Brainstem of Spontaneously Hypertensive Rats

Overview

Journal Science

Specialty Science

Date 1970 Oct 30

PMID 5507206

Citations 15

Authors

Y Yamori

W Lovenberg

A Sjoerdama

Affiliations

Soon will be listed here.

Abstract

Concentrations of norepinephrine in lower brainstem and hypothalamus of genetically hypertensive rats are significantly lower than in control rats. There is a concomitant reduction (50 percent) in aromatic L-amino acid decarboxylase but not in tyrosine hydroxylase activity. A possible relation of this central catecholamine deficiency to the hypertension is discussed.

Citing Articles

Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat.

Jirout M, Friese R, Mahapatra N, Mahata M, Taupenot L, Mahata S Hum Mol Genet. 2010; 19(13):2567-80.

PMID: 20378607 PMC: 2883337. DOI: 10.1093/hmg/ddq135.

Markedly elevated specific renin levels in the adrenal in genetically hypertensive rats.

Naruse M, Inagami T Proc Natl Acad Sci U S A. 1982; 79(10):3295-9.

PMID: 7048303 PMC: 346402. DOI: 10.1073/pnas.79.10.3295.

Norepinephrine level in the hypothalamus of the genetically hypertensive mouse.

Schlager G, Freeman R Experientia. 1983; 39(7):793-4.

PMID: 6861975 DOI: 10.1007/BF01990332.

Modification of the cardiovascular effects of L-dopa by decarboxylase inhibitors.

Watanabe A, Parks L, Kopin I J Clin Invest. 1971; 50(6):1322-8.

PMID: 5578236 PMC: 292063. DOI: 10.1172/JCI106611.

Serum dopamine- -hydroxylase in spontaneously hypertensive rats.

Nagatsu T, Kato T, Kuzuya H, Umezawa H, Matsuzaki M, Takeuchi T Experientia. 1972; 28(8):905-6.

PMID: 5076316 DOI: 10.1007/BF01924936.