Pharmacological Enhancement of Fibrinolytic Activity and 125I-fibrinogen Survival

Overview

Journal J Clin Pathol

Specialty Pathology

Date 1970 Dec 1

PMID 5504373

Citations 1

Authors

J A Hickman

Affiliations

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Abstract

Studies with (125)I-fibrinogen after the administration of phenformin plus ethyloestrenol in five subjects showed no evidence of enhanced catabolism of fibrinogen despite a fall in plasma fibrinogen concentration and shortened clot lysis time. It seems probable that the fall in plasma fibrinogen concentration after the administration of these drugs is related to diminished hepatic synthesis of fibrinogen and is independent of the induction of plasminogen activator release.

Citing Articles

Behaviour of commercially prepared I-125 fibrinogen in metabolic studies.

Bradley J, Hickman J J Clin Pathol. 1975; 28(6):487-93.

PMID: 1141450 PMC: 475748. DOI: 10.1136/jcp.28.6.487.

References

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