Alpha 2.0
Login Register
» Articles » PMID: 5486515

Cyclophosphamide Therapy of Idiopathic Nephrosis

Overview
Journal Calif Med
Date 1970 Dec 1
PMID 5486515
Citations 3
Authors
C M Grushkin
R N Fine
E Heuser
E Lieberman
Affiliations
Soon will be listed here.
Abstract

Thirty-three children with steroid-dependent or steroid-resistant idiopathic nephrosis were treated with a combination of cyclophosphamide and prednisone. Remission occurred in all 23 steroid-dependent patients and, at last report, 12 had gone without any medication for periods of from two months to 21 months without relapse. Remission occurred in five of ten steroid-resistant patients. The renal biopsy findings in these patients demonstrate a correlation between the "minimal change" lesion and a positive response to cyclophosphamide.

Citing Articles

Long-term follow-up after cyclophosphamide and cyclosporine-A therapy in steroid-dependent and -resistant nephrotic syndrome.

Sumegi V, Haszon I, Bereczki C, Papp F, Turi S Pediatr Nephrol. 2008; 23(7):1085-92.

PMID: 18324421 DOI: 10.1007/s00467-008-0771-8.

Treatment of active chronic hepatitis with cyclophosphamide.

Naccarato R, Farini R, Chiaramonte M, Fagiolo U, Sturniolo G Postgrad Med J. 1974; 50(579):16-24.

PMID: 4464495 PMC: 2495510. DOI: 10.1136/pgmj.50.579.16.

The morphological and clinical course of the different forms of glomerulonephritis.

Fishbach H, Bohle A, Meyer D, EDEL H, Frotscher U, KLUTHE R Klin Wochenschr. 1976; 54(3):105-16.

PMID: 1255998 DOI: 10.1007/BF01468787.

References
1.
Grupe W, HEYMANN W . Cytotoxic drugs in steroid-resistant renal disease. Alkylating and antimetabolic agents in the treatment of nephrotic syndrome, lupus nephritis, chronic glomerulonephritis, and purpura nephritis in children. Am J Dis Child. 1966; 112(5):448-58. DOI: 10.1001/archpedi.1966.02090140120011. View
2.
ETTELDORF J, Roy 3rd S, Summitt R, SWEENEY M, Wall H, BERTON W . Cyclophosphamide in the treatment of idiopathic lipoid nephrosis. J Pediatr. 1967; 70(5):758-66. DOI: 10.1016/s0022-3476(67)80327-5. View
3.
DRUMMOND K, Hillman D, MARCHESSAULT J, Feldman W . Cyclophosphamide in the nephrotic syndrome of childhood: its use in two groups of patients defined by clinical, light microscopic and immunopathologic findings. Can Med Assoc J. 1968; 98(11):524-31. PMC: 1923912. View
4.
Lieberman E, Heuser E, Gilchrist G, Donnell G, LANDING B . Thrombosis, nephrosis, and corticosteroid therapy. J Pediatr. 1968; 73(3):320-8. DOI: 10.1016/s0022-3476(68)80107-6. View
5.
Scheinman J, STAMLER F . Cyclophosphamide and fatal varicella. J Pediatr. 1969; 74(1):117-9. DOI: 10.1016/s0022-3476(69)80018-1. View