Purified Rabies Vaccine (suckling Rat Brain Origin)

Overview

Journal Appl Microbiol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1970 Jun 1

PMID 5456012

Citations 1

Authors

J F Lavender

Affiliations

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Abstract

A 10% suckling rat brain rabies vaccine free from encephalitogenic activity was prepared and inactivated with 1:8,000 beta-propiolactone (BPL), or ultraviolet light, or a combination of ultraviolet light and BPL, or 1% phenol. Potency was excellent in all samples, with the exception of the phenolized product which was marginal. A purified suckling rat brain (SRB) vaccine prepared by zonal centrifugation and inactivated with 1:8,000 BPL contained about 0.01 the amount of protein nitrogen of the unpurified 10% SRB vaccine. This purified product passed the National Institutes of Health potency test for rabies vaccine after administration of a quantity equivalent to a standard 10% brain suspension.

Citing Articles

The vaccination of man and other animals against rabies.

Crick J Postgrad Med J. 1973; 49(574):551-64.

PMID: 4207636 PMC: 2495600. DOI: 10.1136/pgmj.49.574.551.

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