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Induction of Kynureninase in Neurospora

Overview
Journal J Bacteriol
Publisher American Society for Microbiology
Specialty Microbiology
Date 1970 Aug 1
PMID 5432006
Citations 11
Authors
J R Turner
W A SORSOLI
W H Matchett
Affiliations
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Abstract

Induction of kynureninase in a homogeneous population of mycelia in balanced growth was studied. Induced synthesis of enzyme was apparent 10 min after addition of inducers (tryptophan, kynurenine, and N-formylkynurenine). Experiments with cycloheximide-inhibited cells indicated that initiation of message transcription occurred about 4 min after addition of inducers. Lifetime of the message in the absence of inducer was of the order of 5 min. Experiments with mutants showed that N-formylkynurenine was the probable inducer of physiological importance.

Citing Articles

Temporal separation of transcription and translation in Neurospora.

Turner J, Terry K, Matchett W J Bacteriol. 1970; 103(2):370-4.

PMID: 5432007 PMC: 248089. DOI: 10.1128/jb.103.2.370-374.1970.

Cross-pathway regulation: histidine-mediated control of histidine, tryptophan, and arginine biosynthetic enzymes in Neurospora crassa.

CARSIOTIS M, Jones R, Wesseling A J Bacteriol. 1974; 119(3):893-98.

PMID: 4368540 PMC: 245696. DOI: 10.1128/jb.119.3.893-898.1974.

Evidence for distinct kynureninase and hydroxykynureninase activities in Neurospora crassa.

Gaertner F, Cole K, Welch G J Bacteriol. 1971; 108(2):902-9.

PMID: 4331500 PMC: 247158. DOI: 10.1128/jb.108.2.902-909.1971.

Occurrence of N-formylkynurenine in extracts of Neurospora crassa: evidence for the activity of tryptophan pyrrolase.

Chen J, Matchett W J Bacteriol. 1974; 118(3):837-43.

PMID: 4275312 PMC: 246830. DOI: 10.1128/jb.118.3.837-843.1974.

Tryptophan metabolism and kynureninase induction in mutants of Neurospora crassa resistant to 4-methyl-tryptophan.

Turner J J Bacteriol. 1973; 115(2):640-7.

PMID: 4269379 PMC: 246294. DOI: 10.1128/jb.115.2.640-647.1973.

References
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BATES W, Hedman S, Woodward D . Comparative inductive responses of two beta-galactosidases of Neurospora. J Bacteriol. 1967; 93(5):1631-7. PMC: 276659. DOI: 10.1128/jb.93.5.1631-1637.1967. View
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Turner J, Matchett W . Alteration of tryptophan-mediated regulation in Neurospora crassa by indoleglycerol phosphate. J Bacteriol. 1968; 95(5):1608-14. PMC: 252184. DOI: 10.1128/jb.95.5.1608-1614.1968. View
3.
Turner J, Terry K, Matchett W . Temporal separation of transcription and translation in Neurospora. J Bacteriol. 1970; 103(2):370-4. PMC: 248089. DOI: 10.1128/jb.103.2.370-374.1970. View
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PARTRIDGE C, Bonner D, Yanofsky C . A quantitative study of the relationship between tryptophan and niacin in Neurospora. J Biol Chem. 1952; 194(1):269-78. View
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Jakoby W, Bonner D . Kynureninase from Neurospora: purification and properties. J Biol Chem. 1953; 205(2):699-707. View