Symptomatic Hypercalcaemia in Thyrotoxicosis

Overview

Journal Br Med J

Specialty General Medicine

Date 1970 Jun 20

PMID 5429653

Citations 7

Authors

R G Twycross

V Marks

Affiliations

Soon will be listed here.

Abstract

In three patients with thyrotoxicosis and with symptomatic hypercalcaemia antithyroid therapy restored the plasma calcium concentration to normal, though initially in one case intravenous and oral neutral phosphate solution were required to curtail intractable vomiting.Nine cases have been recorded in which the plasma calcium concentration returned to normal after antithyroid treatment was started; all but one became normocalcaemic within eight weeks. It is suggested that in hypercalcaemic thyrotoxicosis a second pathological condition should be considered only if the plasma calcium concentration fails to return to normal within eight weeks.

Citing Articles

Causes of anorexia in untreated hyperthyroidism: a prospective study.

Dai W, Meng X Postgrad Med J. 2000; 76(895):292-4.

PMID: 10775283 PMC: 1741582. DOI: 10.1136/pmj.76.895.292.

Hyperemesis gravidarum due to thyrotoxicosis.

Valentine B, Jones C, Tyack A Postgrad Med J. 1980; 56(660):746-7.

PMID: 6784110 PMC: 2426028. DOI: 10.1136/pgmj.56.660.746.

Treatment of hypercalcaemia in thyrotoxicosis with aminohydroxypropylidene diphosphonate.

Tan T, Alzaid A, Sutcliffe N, Gardner M, Thomson J, Boyle I Postgrad Med J. 1988; 64(749):224-7.

PMID: 3174541 PMC: 2428854. DOI: 10.1136/pgmj.64.749.224.

Coexisting hyperparathyroidism with thyrotoxicosis.

McGowan D, Vaswani A, Shperling I J Endocrinol Invest. 1991; 14(4):305-10.

PMID: 1865080 DOI: 10.1007/BF03346819.

Thyrotoxic vomiting.

Br Med J. 1976; 2(6044):1133.

PMID: 990810 PMC: 1689421.

References

DAVID N, VERNER J, ENGEL F . The diagnostic spectrum of hypercalcemia. Case reports and discussion. Am J Med. 1962; 33:88-110. DOI: 10.1016/0002-9343(62)90280-2. View

Aliapoulios M, VOELKEL E, MUNSON P . Assay of human thyroid glands for thyrocalcitonin activity. J Clin Endocrinol Metab. 1966; 26(8):897-901. DOI: 10.1210/jcem-26-8-897. View

PRIBEK R, Meade R . Thyrotoxicosis simulating hyperparathyroidism. AMA Arch Intern Med. 1957; 100(6):994-7. DOI: 10.1001/archinte.1957.00260120138017. View

NIKKILA E, Pitkanen E . Persistent vomiting as a dominant symptom of thyrotoxicosis. A form of masked hyperthyroidism. Ann Med Intern Fenn. 1960; 49:293-300. View

Frizel D, MALLESON A, Marks V . Plasma levels of ionised calcium and magnesium in thyroid disease. Lancet. 1967; 1(7504):1360-1. DOI: 10.1016/s0140-6736(67)91766-7. View

KLOTZ H, Blahos J, DELORME M, Kanovitch D . [Disorders of calcium metabolism in thyroid diseases]. Ann Endocrinol (Paris). 1968; 29(5):624-45. View

Kleeman C, Tuttle S, Bassett S . Metabolic observations in a case of thyrotoxicosis with hypercalcemia. J Clin Endocrinol Metab. 1958; 18(5):477-91. DOI: 10.1210/jcem-18-5-477. View

Buckle R, Mason A, MIDDLETON J . Thyrotoxic hypercalcaemia treated with porcine calcitonin. Lancet. 1969; 1(7606):1128-30. DOI: 10.1016/s0140-6736(69)91646-8. View

Krane S, Brownell G, Stanbury J, Corrigan H . The effect of thyroid disease on calcium metabolism in man. J Clin Invest. 1956; 35(8):874-87. PMC: 441658. DOI: 10.1172/JCI103340. View

10.

SATALINE L, Powell C, HAMWI G . Suppression of the hypercalcemia of thyrotoxicosis by corticosteroids. N Engl J Med. 1962; 267:646-50. DOI: 10.1056/NEJM196209272671304. View

11.

Baxter J, Bondy P . Hypercalcemia of thyrotoxicosis. Ann Intern Med. 1966; 65(3):429-42. DOI: 10.7326/0003-4819-65-3-429. View

12.

AUB J, BAUER W, Heath C, ROPES M . STUDIES OF CALCIUM AND PHOSPHORUS METABOLISM: III. The Effects of the Thyroid Hormone and Thyroid Disease. J Clin Invest. 1929; 7(1):97-137. PMC: 434781. DOI: 10.1172/JCI100223. View

13.

EPSTEIN F, FREEDMAN L, LEVITIN H . Hypercalcemia, nephrocalcinosis and reversible renal insufficiency associated with hyperthyroidism. N Engl J Med. 1958; 258(16):782-5. DOI: 10.1056/NEJM195804172581604. View

14.

AHUJA M, Chopra I . Coexistent hyperthyroidism and hyperparathyroidism. Metabolism. 1968; 17(10):854-66. DOI: 10.1016/0026-0495(68)90150-9. View

15.

BREUER R, McPHERSON H . Hypercalcemia in concurrent hyperthyroidism and hyperparathyroidism. Arch Intern Med. 1966; 118(4):310-3. View

16.

KOENIG M, SCHOLZ D, SALASSA R . Hypercalcemia in hyperthyroidism; review and report of four cases. Minn Med. 1957; 40(11):782-8. View

17.

HUBBLE D, STEINER R . Discussion on skeletal manifestations of general disease. Proc R Soc Med. 1958; 51(7):475-85. PMC: 1889673. View