Regulation of Aromatic Amino Acid Biosynthesis in Phenazine-producing Strains of Pseudomonas

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1970 Jul 1

PMID 5423368

Citations 3

Authors

M E LEVITCH

Affiliations

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Abstract

Regulation of 3-deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) synthetase was studied in eight strains of Pseudomonas which synthesize phenazine compounds. Repression studies with individual aromatic amino acids led to the finding that enzyme synthesis was repressed in only one strain, P. aureofaciens B1543p, and by only one amino acid, l-tyrosine. Feedback inhibition by the aromatic amino acids varied from strain to strain in terms of the type of inhibitory control, and the particular acid or acids which inhibited. Prephenate and chorismate, as well as a number of naturally occurring phenazine compounds, inhibited the DAHP synthetase activity to varying degrees.

Citing Articles

Phenazines and their role in biocontrol by Pseudomonas bacteria.

Chin-A-Woeng T, Bloemberg G, Lugtenberg B New Phytol. 2021; 157(3):503-523.

PMID: 33873412 DOI: 10.1046/j.1469-8137.2003.00686.x.

Mixed carbon source effect in the phenazine-alpha-carboxylic acid synthesis and the aromatic pathway in Pseudomonas spp.

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Role of a phenazine antibiotic from Pseudomonas fluorescens in biological control of Gaeumannomyces graminis var. tritici.

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