Determination of Plasma Concentrations of Dapsone, Monoacetyl Dapsone and Pyrimethamine in Human Subjects Dosed with Maloprim

Overview

Journal J Chromatogr

Date 1979 Jun 11

PMID 541369

Citations 14

Authors

C R Jones

S M Ovenell

Affiliations

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Abstract

A high-performance liquid chromatographic method was developed to enable dapsone, monoacetyl dapsone and pyrimethamine to be measured simultaneously in plasma samples from volunteers in England and Malaysia who had been dosed with Maloprim. Mean half-lives of 25 and 80 h were calculated for dapsone and pyrimethamine, respectively, but there was wide individual variation. All subjects were found to be classifiable as "slow acetylators".

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