Pamamycin: a New Antibiotic and Stimulator of Aerial Mycelia Formation

Overview

Journal J Antibiot (Tokyo)

Specialties Infectious Diseases
Pharmacology

Date 1979 Jul 1

PMID 541261

Citations 6

Authors

P A McCann

B M POGELL

Affiliations

Soon will be listed here.

Abstract

Pamamycin is a new antibiotic isolated from Streptomyces alboniger ATCC 12461. The antibiotic is active in vitro against Gram-positive bacteria, Neurospora, and Mycobacteria. The compound also acts as a streptomycete differentiation effector. It stimulates aerial mycelia formation in the producing organism. The new antibiotic of elemental composition C36H63NO7 is completely different from puromycin, also produced by this strain. The present communication deals with the isolation, properties, and preliminary characterization of pamamycin.

Citing Articles

Superior production of heavy pamamycin derivatives using a bkdR deletion mutant of Streptomyces albus J1074/R2.

Glaser L, Kuhl M, Stegmuller J, Ruckert C, Myronovskyi M, Kalinowski J Microb Cell Fact. 2021; 20(1):111.

PMID: 34082758 PMC: 8176718. DOI: 10.1186/s12934-021-01602-6.

Extremely Low Leakage Expression Systems Using Dual Transcriptional-Translational Control for Toxic Protein Production.

Kato Y Int J Mol Sci. 2020; 21(3).

PMID: 31973139 PMC: 7037476. DOI: 10.3390/ijms21030705.

Dual control system - A novel scaffolding architecture of an inducible regulatory device for the precise regulation of gene expression.

Horbal L, Luzhetskyy A Metab Eng. 2016; 37:11-23.

PMID: 27040671 PMC: 4915818. DOI: 10.1016/j.ymben.2016.03.008.

Recent advances in the biosynthesis of unusual polyketide synthase substrates.

Ray L, Moore B Nat Prod Rep. 2015; 33(2):150-61.

PMID: 26571143 PMC: 4742410. DOI: 10.1039/c5np00112a.

Use of direct-infusion electrospray mass spectrometry to guide empirical development of improved conditions for expression of secondary metabolites from actinomycetes.

Zahn J, Higgs R, Hilton M Appl Environ Microbiol. 2001; 67(1):377-86.

PMID: 11133469 PMC: 92589. DOI: 10.1128/AEM.67.1.377-386.2001.