Alanine: Key Role in Gluconeogenesis

Overview

Journal Science

Specialty Science

Date 1970 Feb 13

PMID 5411169

Citations 157

Authors

P FELIG

T POZEFSKY

E Marliss

G F Cahill Jr

Affiliations

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Abstract

Of 20 amino acids measured, alanine is the principal amino acid released by forearm muscle of man, in accord with its being the principal amino acid extracted by liver for gluconeogenesis. This occurs in both the postabsorptive state and after 4 to 6 weeks of starvation, when total amino acid release is markedly diminished.

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