5-hydroxytryptamine: a Cytospecific Growth Stimulator of Cultured Fibroblasts
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5-Hydroxytryptamine (serotonin) in micromolar amounts increased the growth of fibroblasts in culture while not affecting five other cell lines. Serotonin appeared to shorten the lag phase of cell growth. The effect was less when serotonin was added to the fibroblast culture after the initial 24-hour period. The two functional groups of the serotonin molecule were required for growth enhancement. Serotonin in millimolar concentrations was toxic to fibroblasts.
Towards Physiologic Culture Approaches to Improve Standard Cultivation of Mesenchymal Stem Cells.
Nikolits I, Nebel S, Egger D, Kress S, Kasper C Cells. 2021; 10(4).
PMID: 33924517 PMC: 8069108. DOI: 10.3390/cells10040886.
The influence of season, photoperiod, and pineal melatonin on immune function.
Nelson R, Demas G, Klein S, Kriegsfeld L J Pineal Res. 1995; 19(4):149-65.
PMID: 8789246 PMC: 7166827. DOI: 10.1111/j.1600-079x.1995.tb00184.x.
A murine model of the eosinophilia-myalgia syndrome induced by 1,1'-ethylidenebis (L-tryptophan).
Silver R, Ludwicka A, Hampton M, Ohba T, Bingel S, Smith T J Clin Invest. 1994; 93(4):1473-80.
PMID: 8163652 PMC: 294161. DOI: 10.1172/JCI117125.
Platelets, fibroblasts, and inflammation: tissue reactions to platelets injected subcutaneously.
BRAUNSTEIN P, Cuenoud H, Joris I, Majno G Am J Pathol. 1980; 99(1):53-66.
PMID: 7361863 PMC: 1903476.
Medoff J, Gross J J Cell Biol. 1971; 50(2):457-68.
PMID: 4939524 PMC: 2108271. DOI: 10.1083/jcb.50.2.457.