Effect of Methylamalonic Acid on Gluconeogenesis in Isolated Rat and Guinea-pig Hepatocytes
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Abstract
Gluconeogenesis from pyruvate, alanine, lactate and propionate was inhibited by methylmalonate in both rat and guinea-pig hepatocytes. The effect was dose-dependent. Gluconeogenesis from glycerol and xylitol was not affected.
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References
1.
Williamson J, Anderson J, Browning E
. Inhibition of gluconeogenesis by butylmalonate in perfused rat liver. J Biol Chem. 1970; 245(7):1717-26.
View
2.
Arinze I, Garber A, Hanson R
. The regulation of gluconeogenesis in mammalian liver. The role of mitochondrial phosphoenolpyruvate carboxykinase. J Biol Chem. 1973; 248(7):2266-74.
View
3.
Halperin M, Schiller C, Fritz I
. The inhibition by methylmalonic acid of malate transport by the dicarboxylate carrier in rat liver mitochondria. A possible explantation for hypoglycemia in methylmalonic aciduria. J Clin Invest. 1971; 50(11):2276-82.
PMC: 292169.
DOI: 10.1172/JCI106725.
View
4.
Robinson B, Chappell J
. The inhibition of malate, tricarboxylate and oxoglutarate entry into mitochondria by 2-n-butylmalonate. Biochem Biophys Res Commun. 1967; 28(2):249-55.
DOI: 10.1016/0006-291x(67)90437-8.
View
5.
Hanson R, Garber A
. Phosphoenolpyruvate carboxykinase. I. Its role in gluconeogenesis. Am J Clin Nutr. 1972; 25(10):1010-21.
DOI: 10.1093/ajcn/25.10.1010.
View