Immunological Relationships Between Hexons of Certain Human Adenoviruses

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1969 Nov 1

PMID 5360524

Citations 19

Authors

E Norrby

G Wadell

Affiliations

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Abstract

Antisera against hexons of serotypes 2, 4, 5, and 6 (subgroup III), and 15 (subgroup II) were absorbed with purified hexons of various serotypes representing the different subgroups of human adenoviruses. Group, subgroup, and type specificities of hexons could be distinguished. The subgroup specificity of type 4 hexons resembled that of hexons of subgroup I members (types 3, 11, and 16). Antihexon sera gave a type-specific inhibition of virion-associated hemagglutinin. The inhibiting activity of different sera was found to be inversely related to the length of fibers of the serotype concerned. Virions of serotypes carrying fibers shorter than about 20 nm (types 3, 4, 9, 11, and 15) were readily inhibited, whereas those of serotypes with longer fibers (types 2 and 6) were inhibited only by relatively large amounts of antibody measured in terms of homotypic complement fixation activity. The reciprocal cross-neutralization between serotypes 4 and 16 was studied separately. Hexons of both serotypes each carried a type-specific component and, in addition, a unique antigen specificity common to the two types. This common antigen specificity was interpreted to be available to a larger extent at the surface of virions (and probably also isolated hexons) of type 4 than of type 16. These results suggest an explanation for the predominantly one-sided character of the cross-neutralization between types 4 and 16.

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References

Almeida J, Cinader B, Naylor D . Univalent fragments of antibody: a study by electron microscopy. Immunochemistry. 1965; 2(2):169-76. DOI: 10.1016/0019-2791(65)90018-2. View

Pina M, Green M . Biochemical studies on adenovirus multiplication. IX. Chemical and base composition analysis of 28 human adenoviruses. Proc Natl Acad Sci U S A. 1965; 54(2):547-51. PMC: 219702. DOI: 10.1073/pnas.54.2.547. View

Norrby E . The relationship between the soluble antigens and the virion of adenovirus type 3. I. Morphological characteristics. Virology. 1966; 28(2):236-48. DOI: 10.1016/0042-6822(66)90148-6. View

Norrby E . The relationship between the soluble antigens and the virion of adenovirus type 3. II. Identification and characterization of an incomplete hemagglutinin. Virology. 1966; 30(4):608-17. DOI: 10.1016/0042-6822(66)90165-6. View

Norrby E, Skaaret P . The relationship between soluble antigens and the virion of adenovirus type 3. 3. Immunological identification of fiber antigen and isolated vertex capsomer antigen. Virology. 1967; 32(3):489-502. DOI: 10.1016/0042-6822(67)90301-7. View

Valentine R, Green N . Electron microscopy of an antibody-hapten complex. J Mol Biol. 1967; 27(3):615-7. DOI: 10.1016/0022-2836(67)90063-0. View

Freeman A, Black P, Vanderpool E, Henry P, Austin J, HUEBNER R . Transformation of primary rat embryo cells by adenovirus type 2. Proc Natl Acad Sci U S A. 1967; 58(3):1205-12. PMC: 335769. DOI: 10.1073/pnas.58.3.1205. View

Stevens D, Schaeffer M, Fox J, BRANDT C, Romano M . Standardization and certification of reference antigens and antisera for 30 human adenovirus serotypes. Am J Epidemiol. 1967; 86(3):617-33. DOI: 10.1093/oxfordjournals.aje.a120771. View

La S, Green M . The mechanism of viral carcinogenesis by DNA mammalian viruses: DNA-DNA homology relationships among the "weakly" oncogenic human adenoviruses. J Gen Virol. 1967; 1(4):413-8. DOI: 10.1099/0022-1317-1-4-413. View

10.

Norrby E . Identification of soluble components of adenovirus type 11. J Gen Virol. 1968; 2(1):123-33. DOI: 10.1099/0022-1317-2-1-123. View

11.

Norrby E . Comparison of soluble components of adenovirus types 3 and 11. J Gen Virol. 1968; 2(1):135-42. DOI: 10.1099/0022-1317-2-1-135. View

12.

Kjellen L, Pereira H . Role of adenovirus antigens in the induction of virus neutralizing antibody. J Gen Virol. 1968; 2(1):177-85. DOI: 10.1099/0022-1317-2-1-177. View

13.

Wadell G, Norrby E, Schonning U . Ultrastructure of soluble antigens and the virion of adenovirus type 4. Arch Gesamte Virusforsch. 1967; 21(2):234-42. DOI: 10.1007/BF01241447. View

14.

Norrby E . Biological significance of structural adenovirus components. Curr Top Microbiol Immunol. 1968; 43:1-43. DOI: 10.1007/978-3-642-46118-7_1. View

15.

Wadell G, Skaaret P . Separation of adenovirus type 4 components. Arch Gesamte Virusforsch. 1967; 21(3):366-82. DOI: 10.1007/BF01241737. View

16.

Norrby E, Skaaret P . Comparison between soluble components of adenovirus types 3 and 16 and of the intermediate strain 3-16 (the San Carlos agent). Virology. 1968; 36(2):201-11. DOI: 10.1016/0042-6822(68)90137-2. View

17.

Norby E . Comparative studies on the soluble components of adenovirus types 9 and 15 and the intermediate strain 9-15. J Virol. 1968; 2(10):1200-10. PMC: 375453. DOI: 10.1128/JVI.2.10.1200-1210.1968. View

18.

Dohner L . [Studies on the demonstration of serologic differences between the group antigens from various adenovirus types. II. Demonstration of antigen differences with the complement fixation test in the isofixation technic]. Z Immunitatsforsch Allerg Klin Immunol. 1968; 136(5):451-6. View

19.

SCHLESINGER R . Adenoviruses: the nature of the virion and of controlling factors in productive or abortive infection and tumorigenesis. Adv Virus Res. 1969; 14:1-61. DOI: 10.1016/s0065-3527(08)60556-4. View

20.

Norrby E . The relationship between the soluble antigens and the virion of adenovirus type 3. IV. Immunological complexity of soluble components. Virology. 1969; 37(4):565-76. DOI: 10.1016/0042-6822(69)90274-8. View