» Articles » PMID: 5354873

Changes in Blood Gas Tensions and Functional Residual Capacity Chronic Asthmatics Treated with Disodium Cromoglycate

Overview
Journal Br Med J
Specialty General Medicine
Date 1969 Dec 20
PMID 5354873
Citations 1
Authors
Affiliations
Soon will be listed here.
Abstract

Twenty chronic asthmatic subjects were treated with disodium cromoglycate in open trial. Although in the group as a whole spirometric findings improved, some patients showed a significant increase in arterial oxygen tension or a significant fall in functional residual capacity without any appreciable changes in spirometry. These changes may partly explain the clinical efficacy of this drug.

Citing Articles

Sodium cromoglycate (cromolyn sodium): a review of its mode of action, pharmacology, therapeutic efficacy and use.

Brogden R, Speight T, Avery G Drugs. 1974; 7(3):164-282.

PMID: 4212341 DOI: 10.2165/00003495-197407030-00002.

References
1.
Cumming G, Jones J . The construction and repeatability of lung nitrogen clearance curves. Respir Physiol. 1966; 1(2):238-48. DOI: 10.1016/0034-5687(66)90020-x. View

2.
Woolcock A, Read J . Lung volumes in exacerbations of asthma. Am J Med. 1966; 41(2):259-73. DOI: 10.1016/0002-9343(66)90021-0. View

3.
Kelman G, NUNN J . Nomograms for correction of blood Po2, Pco2, pH, and base excess for time and temperature. J Appl Physiol. 1966; 21(5):1484-90. DOI: 10.1152/jappl.1966.21.5.1484. View

4.
PALMER K, DIAMENT M . Spirometry and blood-gas tensions in bronchial asthma and chronic bronchitis. Lancet. 1967; 2(7512):383-4. DOI: 10.1016/s0140-6736(67)92005-3. View

5.
Howell J, ALTOUNYAN R . A double-blind trial of disodium cromoglycate in the treatment of allergic bronchial asthma. Lancet. 1967; 2(7515):539-42. DOI: 10.1016/s0140-6736(67)90499-0. View