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Glucose-lactose Diauxie in Escherichia Coli

Overview
Journal J Bacteriol
Publisher American Society for Microbiology
Specialty Microbiology
Date 1967 Apr 1
PMID 5340309
Citations 37
Authors
W F LOOMIS Jr
B MAGASANIK
Affiliations
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Abstract

Growth of Escherichia coli in medium containing glucose, at a concentration insufficient to support full growth, and containing lactose, is diauxic. A mutation in the gene, CR, which determines catabolite repression specific to the lac operon, was found to relieve glucose-lactose but not glucose-maltose diauxie. Furthermore, a high concentration of lactose was shown to overcome diauxie in a CR(+) strain. Studies on the induction of beta-galactosidase by lactose suggested that glucose inhibits induction by 10(-2)m lactose. Preinduction of the lac operon was found to overcome this effect. The ability of glucose to prevent expression of the lac operon by reducing the internal concentration of inducer as well as by catabolite repression is discussed.

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References
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MAGASANIK B, Neidhardt F . Inhibitory effect of glucose on enzyme formation. Nature. 1956; 178(4537):801-2. DOI: 10.1038/178801b0. View
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LOOMIS Jr W, MAGASANIK B . THE RELATION OF CATABOLITE REPRESSION TO THE INDUCTION SYSTEM FOR BETA-GALACTOSIDASE IN ESCHERICHIA COLI. J Mol Biol. 1964; 8:417-26. DOI: 10.1016/s0022-2836(64)80205-9. View
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Cohn M, HORIBATA K . Physiology of the inhibition by glucose of the induced synthesis of the beta-galactosideenzyme system of Escherichia coli. J Bacteriol. 1959; 78:624-35. PMC: 290602. DOI: 10.1128/jb.78.5.624-635.1959. View
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Clark D, Marr A . STUDIES ON THE REPRESSION OF BETA-GALACTOSIDASE IN ESCHERICHIA COLI. Biochim Biophys Acta. 1964; 92:85-94. DOI: 10.1016/0926-6569(64)90272-x. View
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LOOMIS Jr W, MAGASANIK B . Genetic control of catabolite repression of the lac operon in Escherichia coli. Biochem Biophys Res Commun. 1965; 20(2):230-4. DOI: 10.1016/0006-291x(65)90351-7. View