Attenuation of the Gamma-butyrolactone-induced Increase in DOPA Accumulation by Chronic Ethanol Administration

Overview

Journal J Neural Transm

Specialties Neurology
Physiology

Date 1979 Jan 1

PMID 528994

Citations 2

Authors

S Liljequist

J Engel

Affiliations

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Abstract

The effect of gamma-butyrolactone (GBL) on the accumulation of dopa after inhibition of aromatic amino acid decarboxylase was studied in rats following chronic treatment with ethanol. The GBL-induced dopa accumulation was significantly decreased in ethanol-treated rats. With the increased duration of the ethanol treatment this effect appears to be more marked in the limbic forebrain. It is suggested that chronic ethanol treatment may produce a decreased sensitivity of central GABA receptors.

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