» Articles » PMID: 5289028

Evaluation of the Effects of Chemical Mutagens on Man: the Long Road Ahead

Overview
Specialty Science
Date 1970 Oct 1
PMID 5289028
Citations 3
Authors
Affiliations
Soon will be listed here.
Abstract

By analogy with the problem of evaluating the genetic risks of radiation, it appears that it will be extremely difficult to assess the mutagenicity for man of the wide range of chemicals to which human populations are currently exposed. Nevertheless, the potential significance of this problem calls for a major effort at such an evaluation.

Citing Articles

Analytic review: some current problems of human population genetics.

Cavalli-Sforza L Am J Hum Genet. 1973; 25(1):82-104.

PMID: 4567614 PMC: 1762215.


Protein mapping by combined isoelectric focusing and electrophoresis of mouse tissues. A novel approach to testing for induced point mutations in mammals.

Klose J Humangenetik. 1975; 26(3):231-43.

PMID: 1093965 DOI: 10.1007/BF00281458.


The protein-mapping-method employed to test for chemically induced point mutations in mice.

Klose J Arch Toxicol. 1977; 38(1-2):53-60.

PMID: 578715 DOI: 10.1007/BF00293663.

References
1.
Vogel F, Jager P . The genetic load of a human population due to cytostatic agents. Humangenetik. 1969; 7(4):287-304. DOI: 10.1007/BF00283551. View

2.
ROHRBORN G . Mutagenicity tests in mice. I. The dominant lethal method and the control problem. Humangenetik. 1968; 6(4):345-61. View

3.
Cattanach B . Induction of paternal sex-chromosome losses and deletions and of autosomal gene mutations by the treatment of mouse post-meiotic germ cells with triethylenemelamine. Mutat Res. 1967; 4(1):73-82. DOI: 10.1016/0027-5107(67)90111-x. View

4.
Schull W, Neel J, Hashizume A . Some further observations on the sex ratio among infants born to survivors of the atomic bombings of Hiroshima and Nagasaki. Am J Hum Genet. 1966; 18(4):328-38. PMC: 1706098. View

5.
Taylor B, Chapman A . Genetic effects of spermatogonial irradiation on growth and age at sexual maturity in rats. Genetics. 1969; 63(2):441-54. PMC: 1212356. DOI: 10.1093/genetics/63.2.441. View