Nitrosoguanidine-induced Mutations in Streptomyces Indicus

Overview

Journal Folia Microbiol (Praha)

Publisher Springer

Specialty Microbiology

Date 1979 Jan 1

PMID 527906

Authors

S Sarkar

S L Chakrabarty

Affiliations

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Abstract

The mutagenic activities of five 1-alkyl derivatives of 3-nitro-1-nitrosoguanidine, viz. methyl, ethyl, propyl, isopentyl and octyl, were tested on Streptomyces indicus. All the compounds were found to be mutagenic. The methyl and ethyl derivatives were most effective regarding mutational frequency. The effectiveness decreased with increasing number of C-atoms in the alkyl group of the mutagens. The compounds tested had a much higher mutagenic efficiency that UV-rays. A marked variation existed in antibiotic activity among the biochemical mutants: increase, decrease or complete absence of such activity were seen.

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