Quantitative Study of Mucosal Structure, Enzyme Activities and Phenylalanine Accumulation in Jejunal Biopsies of Patients with Early and Late Onset Diabetes

Overview

Journal Gut

Specialty Gastroenterology

Date 1979 Nov 1

PMID 527868

Citations 3

Authors

E O Riecken

A Zennek

A Lay

H MENGE

Affiliations

Soon will be listed here.

Abstract

A study of the three-dimensional structure of the upper jejunal mucosa in diabetics has been carried out. The structural findings were related to 14C-L-phenylalanine uptake in vitro, sucrase activity in mucosal homogenates, and the enzyme content of the absorptive cells as measured cytophotometrically. A low grade mucosal transformation of the sprue-type was found, which was associated with decreased sucrase activity, and with no reduction in phenylalanine accumulation. On the other hand the specific activities of alkaline phosphatase, non-specific esterase, and succinic dehydrogenase in the surface cells remained unchanged.

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