Induction of Melanin Synthesis in Albino Mouse Skin by DNA from Pigmented Mice

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1969 Sep 1

PMID 5263001

Citations 4

Authors

E Ottolenghi-Nightingale

Affiliations

Soon will be listed here.

Abstract

Skin cells from albino mouse embryos have been shown to synthesize melanin after exposure to a nucleoprotein fraction of cells from pigmented mice. Although transformed clones were not found in any of 37 control experiments, at least 15 transformations took place in 10 of a series of 49 experiments using undegraded DNA. The active component in the transforming material appears to be DNA because DNase-treated preparations did not induce melanin synthesis.

Citing Articles

Amish albinism: a distinctive autosomal recessive phenotype.

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Hereditary change in Bombyx after treatment with DNA.

NAWA S, Sakaguchi B, YAMADA M, Tsujita M Genetics. 1971; 67(2):221-34.

PMID: 5106080 PMC: 1212545. DOI: 10.1093/genetics/67.2.221.

[Transformations in higher organism].

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Studies of DNA-induced heritable alteration of mammalian cells.

Borenfreund E, Honda Y, STEINGLASS M, Bendich A J Exp Med. 1970; 132(6):1071-89.

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References

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