The Binding of Gitoxin to Human Plasma Proteins

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1979 Nov 1

PMID 520402

Citations 1

Authors

N Verbeke

P Pellegrin

A Vienne

M Lesne

Affiliations

Soon will be listed here.

Abstract

The binding of gitoxin, digitoxin and digoxin to human plasma proteins was measured by ultracentrifugation and equilibrium dialysis. At concentrations in the range of therapeutic plasma levels, protein binding amounted, respectively, to 85, 92 and 20%, the last two values being consistent with data reported in the literature. The affinity of purified human albumin was not significantly different for the three cardiac glycosides tested. No other protein than albumin was found to bind gitoxin in human plasma.

Citing Articles

Hepatic clearance of gitoxin: pharmacokinetic study on rabbit isolated liver. Influence of protein binding and comparison with digoxin.

Pellegrin P, Lesne M Eur J Drug Metab Pharmacokinet. 1983; 8(1):1-8.

PMID: 6861790 DOI: 10.1007/BF03189574.

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