Genetic Control of Lysine Permeases in Saccharomycopsis Lipolytica

Overview

Journal Arch Microbiol

Specialty Microbiology

Date 1979 Aug 6

PMID 518240

Citations 1

Authors

J M Beckerich

M Lambert

H Heslot

Affiliations

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Abstract

In order to obtain strains of Saccharomycopsis lipolytica impaired in the active transport of L-lysine, mutants resistant to a mixture of L-canavanine, L-4-5-transdehydrolysine and L-S-amino ethylcysteine, taken either all three or two by two, were isolated. These compounds were shown previously to be competitive inhibitors of L-lysine uptake. The resistance patterns and excretion capacity of the mutants were established. All mutants behaved as monogenic. Recombination tests indicated that four genes at least were involved. All mutants were impaired in both high and low affinity L-lysine transport systems. Several hypotheses on the functions of these genes are put forward and discussed.

Citing Articles

Genetic and biochemical study of threonine-overproducing mutants of Saccharomyces cerevisiae.

Delgado M, Guerrero J, Conde J Mol Cell Biol. 1982; 2(7):731-6.

PMID: 6821505 PMC: 369854. DOI: 10.1128/mcb.2.7.731-736.1982.

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