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Protective Role of Ceruloplasmin in Inflammation

Overview
Journal Agents Actions
Specialty Pharmacology
Date 1979 Oct 1
PMID 517330
Citations 25
Authors
C W DENKO
Affiliations
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Abstract

Experimental inflammation in copper (Cu)-deficient rats is greater than that induced in controls eating normal diet. Cu-supplementation of the Cu-deficient diet results in a reduced swelling, down to normal levels. Injection of the naturally occurring acute phase reactant, ceruloplasmin (Cp) a Cu-bearing serum protein, also results in reduction of experimental inflammation. Since a rise in serum Cp occurs in normal pregnancy this protective anti-inflammatory action of Cp is proposed as an explanation for the widely-observed phenomenon of spontaneous control of rheumatoid arthritis in pregnancy.

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References
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