Changes of the Smooth Endoplasmic Reticulum Induced by Rifampicin in Human and Guinea-pig Hepatocytes

Overview

Journal Gut

Specialty Gastroenterology

Date 1971 Dec 1

PMID 5157136

Citations 26

Authors

A M JEZEQUEL

F Orlandi

L T TENCONI

Affiliations

Soon will be listed here.

Abstract

Rifampicin induces a proliferation of the smooth endoplasmic reticulum in guinea-pig and human hepatocytes. This may support the hypothesis of enhancement of drug-metabolizing enzymes induced by the drug. However, the pattern of proliferation is not similar in man and in guinea-pig hepatocytes. Some caution is needed in the study of enzyme induction in man and in extrapolations from animal to human data.

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References

Acocella G, NICOLIS F, TENCONI L . The effect of an intravenous infusion of rifamycin SV on the excretion of bilirubin, bromsulphalein, and indocyanine green in man. Gastroenterology. 1965; 49(5):521-5. View

Acocella G, Billing B . The effect of rifamycin SV on pigment excretion in rats. Gastroenterology. 1965; 49(5):526-30. View

Whelton M, Krustev L, Billing B . Reduction in serum bilirubin by phenobarbital in adult unconjugated hyperhilirubinaemia. Is enzyme induction responsible?. Am J Med. 1968; 45(1):160-4. DOI: 10.1016/0002-9343(68)90017-x. View

Rubin E, Lieber C . Hepatic microsomal enzymes in man and rat: induction and inhibition by ethanol. Science. 1968; 162(3854):690-1. DOI: 10.1126/science.162.3854.690. View

CRIGLER Jr J, Gold N . Effect of sodium phenobarbital on bilirubin metabolism in an infant with congenital, nonhemolytic, unconjugated hyperbilirubinemia, and kernicterus. J Clin Invest. 1969; 48(1):42-55. PMC: 322190. DOI: 10.1172/JCI105973. View

Rubin E, HUTTERER F, Lieber C . Ethanol increases hepatic smooth endoplasmic reticulum and drug-metabolizing enzymes. Science. 1968; 159(3822):1469-70. DOI: 10.1126/science.159.3822.1469. View

CURCI G, NINNI A, Iodice F . [Pharmacokinetics of rifomycin]. Acta Tuberc Pneumol Belg. 1969; 60(3):276-87. View

Stenger R . Organelle pathology of the liver. The endoplasmic reticulum. Gastroenterology. 1970; 58(4):554-74. View

Ma M, BIEMPICA L . The normal human liver cell. Cytochemical and ultrastructural studies. Am J Pathol. 1971; 62(3):353-90. PMC: 2047424. View

10.

FURESZ S . Chemical and biological properties of rifampicin. Antibiot Chemother. 1970; 16:316-51. DOI: 10.1159/000386837. View

11.

Remmer H, Merker H . DRUG-INDUCED CHANGES IN THE LIVER ENDOPLASMIC RETICULUM: ASSOCIATION WITH DRUG-METABOLIZING ENZYMES. Science. 1963; 142(3600):1657-8. DOI: 10.1126/science.142.3600.1657. View

12.

Remmer H, Merker H . EFFECT OF DRUGS ON THE FORMATION OF SMOOTH ENDOPLASMIC RETICULUM AND DRUG-METABOLIZING ENZYMES. Ann N Y Acad Sci. 1965; 123:79-97. DOI: 10.1111/j.1749-6632.1965.tb12247.x. View