Endocrine Control of Lysosomal Alterations in Rat Liver During the Perinatal Period

Overview

Journal Experientia

Specialty Science

Date 1979 Nov 15

PMID 510512

Authors

D Bal

R Vaillant

Affiliations

Soon will be listed here.

Abstract

Within hours of birth, some physical properties of liver lysosomes are modified. These alterations, which may be related to the autophagic vacuoles formation known to occur during this period, were inhibited by insulin administration. Glucagon, a potent inducer of autophagy in adult rat liver, did not anticipate this process in fetal liver. Our results suggest that the decrease of plasma insulin immediately after birth is an important factor in the development of hepatic autophagy.

References

Grammeltvedt R, Berg T . Influence of insulin on lysosomal activity and urea production in isolated parenchymal cells from rat liver. Hoppe Seylers Z Physiol Chem. 1976; 357(7):977-81. DOI: 10.1515/bchm2.1976.357.2.977. View

Deter R . Quantitative characterization of dense body, autophagic vacuole, and acid phosphatase-bearing particle populations during the early phases of glucagon-induced autophagy in rat liver. J Cell Biol. 1971; 48(3):473-89. PMC: 2108109. DOI: 10.1083/jcb.48.3.473. View

Amherdt M, Harris V, Renold A, Orci L, Unger R . Hepatic autography in uncontrolled experimental diabetes and its relationships to insulin and glucagon. J Clin Invest. 1974; 54(1):188-93. PMC: 301539. DOI: 10.1172/JCI107742. View

Bernaert D, Wanson J, DROCHMANS P, Popowski A . Effect of insulin on ultrastructure and glycogenesis in primary cultures of adult rat hepatocytes. J Cell Biol. 1977; 74(3):878-900. PMC: 2110106. DOI: 10.1083/jcb.74.3.878. View

Bal D, Vaillant R . [Intracellular distribution of two lysosomal enzymes in newborn rat liver]. C R Acad Hebd Seances Acad Sci D. 1978; 286(19):1371-4. View

JEZEQUEL A, Arakawa K, Steiner J . The fine structure of the normal, neonatal mouse liver. Lab Invest. 1965; 14(11):1894-930. View

GIANETTO R, DE DUVE C . Tissue fractionation studies. 4. Comparative study of the binding of acid phosphatase, beta-glucuronidase and cathepsin by rat-liver particles. Biochem J. 1955; 59(3):433-8. PMC: 1216262. DOI: 10.1042/bj0590433. View

Girard J, Cuendet G, Marliss E, Kervran A, Rieutort M, Assan R . Fuels, hormones, and liver metabolism at term and during the early postnatal period in the rat. J Clin Invest. 1973; 52(12):3190-200. PMC: 302595. DOI: 10.1172/JCI107519. View

Phillips M, UNAKAR N, Doornewaard G, Steiner J . Glycogen depletion in the newborn rat liver: an electron microscopic and electron histochemical study. J Ultrastruct Res. 1967; 18(1):142-65. DOI: 10.1016/s0022-5320(67)80236-3. View

10.

Deter R, DE DUVE C . Influence of glucagon, an inducer of cellular autophagy, on some physical properties of rat liver lysosomes. J Cell Biol. 1967; 33(2):437-49. PMC: 2108350. DOI: 10.1083/jcb.33.2.437. View

11.

Blazquez E, Montoya E, LOPEZ QUIJADA C . Relationship between insulin concentrations in plasma and pancreas of oetal and weanling rats. J Endocrinol. 1970; 48(4):553-61. DOI: 10.1677/joe.0.0480553. View

12.

Guder W, Hepp K, Wieland O . The catabolic action of glucagon in rat liver. The influence of age, nutritional state and adrenal function on the effect of glucagon on lysosomal N-acetyl-beta, D-glucosaminidase. Biochim Biophys Acta. 1970; 222(3):593-605. View

13.

LOWRY O, ROSEBROUGH N, FARR A, RANDALL R . Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193(1):265-75. View

14.

Deter R, Baudhuin P, DE DUVE C . Participation of lysosomes in cellular autophagy induced in rat liver by glucagon. J Cell Biol. 1967; 35(2):C11-6. PMC: 2107130. DOI: 10.1083/jcb.35.2.c11. View

15.

Findlay J, Levvy G, Marsh C . Inhibition of glycosidases by aldonolactones of corresponding configuration. 2. Inhibitors of beta-N-acetylglucosaminidase. Biochem J. 1958; 69(3):467-76. PMC: 1196579. DOI: 10.1042/bj0690467. View

16.

Ericsson J . Studies on induced cellular autophagy. I. Electron microscopy of cells with in vivo labelled lysosomes. Exp Cell Res. 1969; 55(1):95-106. DOI: 10.1016/0014-4827(69)90462-5. View

17.

ASHFORD T, PORTER K . Cytoplasmic components in hepatic cell lysosomes. J Cell Biol. 1962; 12:198-202. PMC: 2106008. DOI: 10.1083/jcb.12.1.198. View