Changes in Structure and Peptidase Activity of Rat Small Intestine Induced by Prednisolone

Overview

Journal Gut

Specialty Gastroenterology

Date 1971 Jun 1

PMID 5090868

Citations 3

Authors

A J Wall

T J Peters

Affiliations

Soon will be listed here.

Abstract

Chronic dietary administration of prednisolone to the adult rat caused alteration in morphology and enzyme activity of the small intestinal mucosa. Reduction of villous height, crypt depth, and surface epithelial cell height was accompanied by a significant increase in the specific activity of several jejunal peptidases.

Citing Articles

Changes in sucrase, enterokinase, and peptide hydrolase after intestinal resection. The association of cellular hyperplasia and adaptation.

McCarthy D, Kim Y J Clin Invest. 1973; 52(4):942-51.

PMID: 4693657 PMC: 302342. DOI: 10.1172/JCI107259.

Influence of triamcinolone and somatostatin on morphometric parameters of cultured intestinal mucosa.

Schneider A, Grosch G, Stange E, DITSCHUNEIT H In Vitro Cell Dev Biol. 1986; 22(11):647-52.

PMID: 2877965 DOI: 10.1007/BF02623478.

Enhancement of ileal adaptation by prednisolone after proximal small bowel resection in the rat.

Scott J, Batt R, Peters T Gut. 1979; 20(10):858-64.

PMID: 533697 PMC: 1412716. DOI: 10.1136/gut.20.10.858.

References

Bellamy D, Leonard R . The action of corticosteroids on proteolysis. Biochem J. 1966; 98(2):581-6. PMC: 1264880. DOI: 10.1042/bj0980581. View

Lenard J, Johnson S, HYMAN R, Hess G . A CONTINUOUS, AUTOMATIC METHOD FOR THE STUDY OF RATE OF HYDROLYSIS OF PEPTIDES AND AMIDES. Anal Biochem. 1965; 11:30-41. DOI: 10.1016/0003-2697(65)90039-4. View

TALANTI S, HOPSU V . Leucine aminopeptidase in the gastric muscosa of the adrenalectomized rat. Endocrinology. 1961; 68:184-5. DOI: 10.1210/endo-68-1-184. View

FRAZER A . On the growth defect in coelic disease. Proc R Soc Med. 1956; 49(12):1009-13. PMC: 1889278. View

Hoffbrand A, Peters T . The subcellular localization of pteroyl polyglutamate hydrolase and folate in guinea pig intestinal mucosa. Biochim Biophys Acta. 1969; 192(3):479-85. DOI: 10.1016/0304-4165(69)90397-3. View

RAGINS H, Wincze F . Effect of cortisone on the turnover of gastric parietal cells in the mouse. Endocrinology. 1969; 84(1):83-90. DOI: 10.1210/endo-84-1-83. View

GOLDBARG J, RUTENBURG A . The colorimetric determination of leucine aminopeptidase in urine and serum of normal subjects and patients with cancer and other diseases. Cancer. 1958; 11(2):283-91. DOI: 10.1002/1097-0142(195803/04)11:2<283::aid-cncr2820110209>3.0.co;2-8. View

BUCHER N . REGENERATION OF MAMMALIAN LIVER. Int Rev Cytol. 1963; 15:245-300. DOI: 10.1016/s0074-7696(08)61119-5. View

HECHTER O, HALKERSTON I . EFFECTS OF STEROID HORMONES ON GENE REGULATION AND CELL METABOLISM. Annu Rev Physiol. 1965; 27:133-62. DOI: 10.1146/annurev.ph.27.030165.001025. View

10.

Wall A, Douglas A, Booth C, Pearse A . Response of the jejunal mucosa in adult coeliac disease to oral prednisolone. Gut. 1970; 11(1):7-14. PMC: 1411366. DOI: 10.1136/gut.11.1.7. View

11.

Moog F, Grey R . Alkaline phosphatase isozymes in the duodenum of the mouse: attainment of pattern of spatial distribution in normal development and under the influence of cortisone or actinomycin D. Dev Biol. 1968; 18(5):481-500. DOI: 10.1016/0012-1606(68)90053-5. View

12.

Pina E, Hamabata A, Laguna J . Effect of low concentration of steroids on the activity of glycylglycine dipeptidase in vitro. Biochem Biophys Res Commun. 1962; 9:447-50. DOI: 10.1016/0006-291x(62)90032-3. View

13.

LOWRY O, ROSEBROUGH N, FARR A, RANDALL R . Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193(1):265-75. View

14.

SCHWARTZ T, Robertson M, Holmes L . Adrenocortical influences on dipeptidase activity of surviving rat diaphragm. Endocrinology. 1956; 58(4):453-60. DOI: 10.1210/endo-58-4-453. View

15.

IZZO J, GLASSER S . Comparative effects of glucagon, hydrocortisone and epinephrine on the protein metabolism of the fasting rat. Endocrinology. 1961; 68:189-98. DOI: 10.1210/endo-68-2-189. View

16.

Roy A . The sulphatase of ox liver. I. The complex nature of the enzyme. Biochem J. 1953; 53(1):12-5. PMC: 1198092. DOI: 10.1042/bj0530012. View