Stimulatory Effect of Pancreozymin-cholecystokinin on Calcium Secretion in Pancreatic Juice of Dogs

Overview

Journal Gut

Specialty Gastroenterology

Date 1972 Jun 1

PMID 5040835

Citations 7

Authors

H Goebell

C Steffen

C Bode

Affiliations

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Abstract

In four dogs with a permanent duodenal Thomas fistula the secretion of calcium, sodium, potassium, protein, and two pancreatic enzymes in pancreatic juice was studied. Infusion of secretin led to a decrease in concentration of calcium and of protein with increasing rates of fluid production. Pancreozymin-cholecystokinin was given in single injections superimposed on the secretin-stimulated flow of juice. This hormone stimulated the secretion of both calcium and enzyme protein in a parallel and closely correlated fashion. The secretion of this protein-bound calcium fraction I is assumed to occur in the acinar cell. A calcium fraction II, which was independent of protein secretion and pancreozymin stimulation, was demonstrated in concentrations of about 0.4 to 0.6 m-equiv/l. This fraction is thought to originate in the interstitial fluid. The secretion of two calcium-containing fluids is in accordance with the two-component theory of secretion proposed by Hollander and Birnbaum (1952).

Citing Articles

Influence of pancreatic ducts on saturation of juice with calcium carbonate in dogs.

Marteau C, Blanc G, Devaux M, PORTUGAL H, GEROLAMI A Dig Dis Sci. 1993; 38(11):2090-7.

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Effects of morphine on human pancreatic secretion: studies on pure pancreatic juice.

Gullo L, Priori P, Costa P, Garcea D, Baldoni F, Mattioli G Gut. 1982; 23(9):739-43.

PMID: 7106620 PMC: 1419752. DOI: 10.1136/gut.23.9.739.

[Magnesium and calcium in duodenal juice: secretion pattern in chronic pancreatitis and in primary hyperparathyroidism (author's transl)].

BALTZER G, Goebell H Klin Wochenschr. 1974; 52(2):74-9.

PMID: 4816958 DOI: 10.1007/BF01468329.

Amylase secretion by the perfused cat pancreas in relation to the secretion of calcium and other electrolytes and as influenced by the external ionic environment.

Argent B, Case R, Scratcherd T J Physiol. 1973; 230(3):575-93.

PMID: 4717152 PMC: 1350616. DOI: 10.1113/jphysiol.1973.sp010205.

Hypersecretion of zymogen granules in the pathogenesis of cystic fibrosis.

BLOMFIELD J, Dascalu J, van Lennep E, Brown J Gut. 1973; 14(7):558-65.

PMID: 4354146 PMC: 1412812. DOI: 10.1136/gut.14.7.558.

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