Coronary Vasodilator Responses to Hypoxia Before and After Aminophylline

Overview

Journal J Physiol

Specialty Physiology

Date 1972 Mar 1

PMID 5016362

Citations 10

Authors

S Afonso

T J Ansfield

T B Berndt

G G ROWE

Affiliations

Soon will be listed here.

Abstract

1. In previous studies adenosine has been postulated to be the mediator in coronary blood flow regulation and aminophylline was found to inhibit the coronary vasodilator action of adenosine. The present study was performed to determine whether aminophylline inhibits coronary vasodilatation induced by hypoxia.2. Coronary and systemic haemodynamic and metabolic effects of hypoxia were studied in anaesthetized dogs before and after aminophylline. Aminophylline did not influence coronary vasodilatation induced by hypoxia.3. These results are held not to lend support to the hypothesis that adenosine is the metabolite responsible for the regulation of coronary blood flow.

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References

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Afonso S . Coronary vasodilator responses to hypoxia and induced tachycardia before and after lidoflazine. Am J Physiol. 1969; 216(2):297-300. DOI: 10.1152/ajplegacy.1969.216.2.297. View

Rubio R, BERNE R . Release of adenosine by the normal myocardium in dogs and its relationship to the regulation of coronary resistance. Circ Res. 1969; 25(4):407-15. DOI: 10.1161/01.res.25.4.407. View

Afonso S . Inhibition of coronary vasodilating action of dipyridamole and adenosine by aminophylline in the dog. Circ Res. 1970; 26(6):743-52. DOI: 10.1161/01.res.26.6.743. View