Virus-associated Nucleases: Evidence for Endonuclease and Exonuclease Activity in Rabbitpox and Vaccinia Viruses

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1972 Mar 1

PMID 5015715

Citations 9

Authors

A M Aubertin

B R McAuslan

Affiliations

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Abstract

The endonucleolytic action of a deoxyribonuclease activity in rabbitpox and vaccinia virus was established by change in sedimentation rate of denatured (3)H-lambda deoxyribonucleic acid substrate. The presence of two deoxyribonuclease activities in pox-virus is confirmed. Exo- and endonuclease activities are unmasked by treatment of purified virus with the detergent Nonidet P-40 and further enhanced by treatment of viral "cores" with trypsin.

Citing Articles

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Shope fibroma virus. II. Role of the virion-associated nucleases.

POGO B, Stein A, Freimuth P J Virol. 1982; 41(1):104-9.

PMID: 6283106 PMC: 256730. DOI: 10.1128/JVI.41.1.104-109.1982.

Some enzymatic activities associated with purified parapoxvirions.

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Protein kinase and specific phosphate acceptor proteins associated with vaccinia virus cores.

Paoletti E, Moss B J Virol. 1972; 10(3):417-24.

PMID: 5072434 PMC: 356481. DOI: 10.1128/JVI.10.3.417-424.1972.

Breakdown of HeLa cell DNA mediated by vaccinia virus.

Parkhurst J, PETERSON A, HEIDELBERGER C Proc Natl Acad Sci U S A. 1973; 70(11):3200-4.

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References

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