Immunological Characterization of Mononuclear Cells and Morphological Findings in Patients with Mammary Carcinoma

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 1979 Sep 1

PMID 500770

Citations 2

Authors

W Heidenreich

K Jagla

J Schussler

P Borner

F DEHNHARD

J Deinhardt

J Kalden

H H Peter

H Deicher

Affiliations

Soon will be listed here.

Abstract

Mononuclear cells from peripheral blood and draining lymph nodes of 40 patients with invasive mammary carcinoma were examined for various immunological cell surface markers including surface membrane immunoglobulins and rosetting properties (E, EA, EAC). No significant relationship could be established to anyone of the following criteria for which the literature reports varying prognostic values: Clinical staging of the disease , histological tumor type, grading, nuclear differentiation, round cell infiltration, perivenous infiltration, sinus histiocytosis, and lymph node reaction patterns (lymphocyte predominance, germinal center predominance, lymphocyte depletion, unstimulated nodes). From the reported results it is concluded that the analysis of lymphocyte cell surface markers in mammary carcinoma is not a suitable parameter for supporting the existence of specific or unspecific anti-tumor immune reactions which may be suspected from certain histological reaction patterns.

Citing Articles

Mononuclear stromal reactions in mammary carcinoma, with special reference to medullary carcinomas with a lymphoid infiltrate. Analysis of 108 cases.

BASSLER R, Dittmann A, Dittrich M Virchows Arch A Pathol Anat Histol. 1981; 393(1):75-91.

PMID: 7347444 DOI: 10.1007/BF00430872.

[Immunologic significance of the inflammatory stromal reaction in malignant tumors].

Stosiek P, Varga A, Kasper M Klin Wochenschr. 1983; 61(3):157-62.

PMID: 6843042 DOI: 10.1007/BF01486370.

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