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Nuclear Involvement Poin Xvirus Infection

Overview
Journal Proc Natl Acad Sci U S A
Specialty Science
Date 1971 Jan 1
PMID 4993213
Citations 6
Authors
K H WALEN
Affiliations
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Abstract

During the first hours of infection with vaccinia virus, part of the chromosomal DNA of host cells is degraded, part of it is released from the cell, and part of it eventually appears in cytoplasmic foci associated with the reproduction of virus. The DNA of the infecting particle is first found attached to the chromosomes. Intranuclear foci of DNA incorporation appear later; these rapidly move out into the perinuclear space and eventually become typical cytoplasmic "virus factories." Each of these observations points to a more direct involvement of the nucleus in viral infection than was previously envisaged.

Citing Articles

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Mechanism of Shope fibroma virus-induced suppression of host deoxyribonucleic acid synthesis.

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Failure of poxvirus replication in the presence of an inhibitor of nucleolar RNA synthesis.

Nishigori H, Nishimura C Arch Virol. 1977; 53(1-2):163-6.

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Vaccinia virus infection of HeLa cells. I. Synthesis of vaccinia DNA in host cell nuclei.

LaColla P, Weissbach A J Virol. 1975; 15(2):305-15.

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