Studies of Lp-lipoprotein As a Quantitative Genetic Trait

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1970 May 1

PMID 4991520

Citations 12

Authors

N R Harvie

J S Schultz

Affiliations

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Abstract

Sera from 11 individuals which were classified as Lp(a-) by direct gel diffusion and by absorption tests showed the presence of Lp(a) lipoprotein when the sera were concentrated 120-fold. This Lp(a) antigen was demonstrated by gel diffusion to be indistinguishable from Lp-lipoprotein isolated from known Lp(a+) sera. The Lp(a) preparations from sera classified Lp(a-) also showed electrophoretic mobility in immunoelectrophoresis and schlieren diagrams in ultracentrifugal analyses similar to Lp-lipoprotein from Lp(a+) sera. The proposal is made that observed individual variations in tests for the Lp-lipoprotein reflect a quantitative genetic trait and that it is likely that different individuals produce Lp-lipoprotein in widely varying amounts. The consistency of this proposal with certain previous observations on the Lp system is discussed.

Citing Articles

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Neutralization of bacteria- and endotoxin-induced hypotension by lipoprotein-free human serum.

Abdelnoor A, Harvie N, Johnson A Infect Immun. 1982; 38(1):157-61.

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Studies on the Lp(a)-lipoprotein of human serum. IV. The disaggregation of the Lp(a)-lipoprotein.

Utermann G, Lipp K, Wiegandt H Humangenetik. 1972; 14(2):142-50.

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Quantitative genetic studies of the human plasma Lp(a) lipoprotein.

Albers J, Wahl P, Hazzard W Biochem Genet. 1974; 11(6):475-86.

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Immunochemical quantification of human plasma Lp(a) lipoprotein.

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References

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