Changes in Gut Flora After Cephalexin Treatment

Overview

Journal Br Med J

Specialty General Medicine

Date 1970 Sep 12

PMID 4990379

Citations 8

Authors

H Gaya

P I Adnitt

P Turner

Affiliations

Soon will be listed here.

Abstract

Eighteen patients with urinary tract infection were treated with cephalexin orally. Absorption was variable, between 29 and 89% of the total daily dose being excreted in the urine in 24 hours. A significant number of patients became faecal carriers of Pseudomonas aeruginosa compared with a control group who received no antibiotics. Four of the cephalexin-treated patients acquired a strain of Ps. aeruginosa known to be present in food from the hospital diet kitchen and one developed a urinary tract infection with this strain.

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References

Shooter R, Walker K, Williams V, Horgan G, PARKER M, ASHESHOV E . Faecal carriage of Pseudomonas aeruginosa in hospital patients. Possible spread from patient to patient. Lancet. 1966; 2(7477):1331-4. DOI: 10.1016/s0140-6736(66)92082-4. View

Shooter R, Gaya H, Cooke E, Kumar P, Patel N, PARKER M . Food and medicaments as possible sources of hospital strains of Pseudomonas aeruginosa. Lancet. 1969; 1(7608):1227-9. DOI: 10.1016/s0140-6736(69)92114-x. View

Levison M, Johnson W, Thornhill T, Kaye D . Clinical and in vitro evaluation of cephalexin. A new orally administered cephalosporin antibiotic. JAMA. 1969; 209(9):1331-6. View

Kind A, Kestle D, Standiford H, KIRBY W . Laboratory and clinical experience with cephalexin. Antimicrob Agents Chemother (Bethesda). 1968; 8:361-5. View

Gower P, Dash C . Cephalexin: human studies of absorption and excretion of a new cephalosporin antibiotic. Br J Pharmacol. 1969; 37(3):738-47. PMC: 1703714. DOI: 10.1111/j.1476-5381.1969.tb08513.x. View