Uncoupling of an Epithelial Cell Membrane Junction by Calcium-ion Removal

Overview

Journal Science

Specialty Science

Date 1966 Jan 7

PMID 4956066

Citations 6

Authors

M NAKAS

S Higashino

W R Loewenstein

Affiliations

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Abstract

Calcium takes part in maintaining ion communication between salivary gland cells (Chironomus thummi). Its withdrawal from the cell systems results in virtual disconnection of ion communication, at Ca(++) concentrations which do not noticeably affect cell adhesion. The junctional membrane surfaces. which are normally quite freely permeable to ions, become as impermeable as the nonjunctional membrane surfaces; each cell seals itself off irreversibly as a unit. In maintaining ion communication Mg(++) substitutes for Ca(++)

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