Inhibition of Host Deoxyribonucleic Acid Synthesis by T4 Bacteriophage in the Absence of Protein Synthesis

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1971 Nov 1

PMID 4943684

Citations 4

Authors

D H Duckworth

Affiliations

Soon will be listed here.

Abstract

The requirement for phage protein synthesis for the inhibition of host deoxyribonucleic acid synthesis has been investigated by using a phage mutant unable to catalyze the production of any phage deoxyribonucleic acid. It has been concluded that the major pathway whereby phage inhibit host syntheses requires protein synthesis. The inhibition of host syntheses by phage ghosts is not affected by inhibitors of protein synthesis.

Citing Articles

Bacteriophage T4 inhibits colicin E2-induced degradation of Escherichia coli deoxyribonucleic acid. II. Inhibition by T4 ghosts and by T4 in the absence of protein synthesis.

SWIFT R, Wiberg J J Virol. 1973; 11(3):386-98.

PMID: 4570926 PMC: 355114. DOI: 10.1128/JVI.11.3.386-398.1973.

Inhibition of induction of group A bacteriocins of Serratia marcescens by rifampin.

Traub W Experientia. 1972; 28(8):986-8.

PMID: 4561798 DOI: 10.1007/BF01924990.

Mutants of bacteriophage T4 deficient in the ability to induce nuclear disruption: shutoff of host DNA and protein synthesis gene dosage experiments, identification of a restrictive host, and possible biological significance.

Snustad D, Bursch C, Parson K, Hefeneider S J Virol. 1976; 18(1):268-88.

PMID: 768523 PMC: 515546. DOI: 10.1128/JVI.18.1.268-288.1976.

Shutoff of host macromolecular synthesis after T-even bacteriophage infection.

Koerner J, Snustad D Microbiol Rev. 1979; 43(2):199-223.

PMID: 390354 PMC: 281471. DOI: 10.1128/mr.43.2.199-223.1979.

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