The Selective Inhibition of Protein Initiation by T4 Phage-induced Factors

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1970 Oct 1

PMID 4943180

Citations 7

Authors

E B Klem

W T Hsu

S B Weiss

Affiliations

Soon will be listed here.

Abstract

The phenomenon of selective translation of T4 template RNA by ribosomes from T4-infected cells, or factors derived therefrom, has been extended to studies on the initiation of protein synthesis. A high-salt extract derived from T4-infected ribosomes inhibits the formation of initiation complexes of MS2 and Escherichia coli template RNA with uninfected ribosomes while efficiently supporting the formation of initiation complexes with T4 template RNA. T4 factors also permit T5 template RNA to bind to E. coli ribosomes, which indicates that the T4 selective effect is not exclusive for T4 templates. Other evidence indicates that T4 factors do not alter the process of polypeptide chain elongation.

Citing Articles

Inhibition of replication of ribonucleic acid bacteriophage f2 by superinfection with bacteriophage T4.

Goldman E, Lodish H J Virol. 1971; 8(4):417-29.

PMID: 4943076 PMC: 376215. DOI: 10.1128/JVI.8.4.417-429.1971.

Polypeptide synthesis by extracts from Escherichia coli treated with T2 ghosts.

Nugent K, Kennell D J Virol. 1972; 10(6):1199-204.

PMID: 4566438 PMC: 356601. DOI: 10.1128/JVI.10.6.1199-1204.1972.

Effect of elevated temperatures on protein synthesis in Escherichia coli.

Patterson D, Gillespie D J Bacteriol. 1972; 112(3):1177-83.

PMID: 4565533 PMC: 251546. DOI: 10.1128/jb.112.3.1177-1183.1972.

Initiation factor IF-3-dependent binding of Escherichia coli ribosomes and N-formylmethionine transfer-RNA to rabbit globin messenger.

Noll M, NOLL H, Lingrel J Proc Natl Acad Sci U S A. 1972; 69(7):1843-7.

PMID: 4558660 PMC: 426815. DOI: 10.1073/pnas.69.7.1843.

Translation of the genome of a ribonucleic acid bacteriophage.

Kozak M, Nathans D Bacteriol Rev. 1972; 36(1):109-34.

PMID: 4555183 PMC: 378432. DOI: 10.1128/br.36.1.109-134.1972.

References

Schedl P, Singer R, CONWAY T . A factor required for the translation of bacteriophage f2 RNA in extracts of T4-infected cells. Biochem Biophys Res Commun. 1970; 38(4):631-7. DOI: 10.1016/0006-291x(70)90627-3. View

WAINFAN E, Srinivasan P, BOREK E . Alterations in the transfer ribonucleic acid methylases after bacteriophage infection or induction. Biochemistry. 1965; 4(12):2845-8. DOI: 10.1021/bi00888a040. View

Iwasaki K, Sabol S, Wahba A, Ochoa S . Translation of the genetic message. VII. Role of initiation factors in formation of the chain initiation complex with Escherichia coli ribosomes. Arch Biochem Biophys. 1968; 125(2):542-7. DOI: 10.1016/0003-9861(68)90612-7. View

Hattman S, Hofschneider P . Interference of bacteriophage T4 in the reproduction of RNA-phage M12. J Mol Biol. 1967; 29(1):173-90. DOI: 10.1016/0022-2836(67)90189-1. View

KANO-SUEOKA T, Sueoka N . Modification of leucyl-sRNA after bacteriophage infection. J Mol Biol. 1966; 20(1):183-209. DOI: 10.1016/0022-2836(66)90124-0. View

Nirenberg M, Leder P . RNA CODEWORDS AND PROTEIN SYNTHESIS. THE EFFECT OF TRINUCLEOTIDES UPON THE BINDING OF SRNA TO RIBOSOMES. Science. 1964; 145(3639):1399-407. DOI: 10.1126/science.145.3639.1399. View

TILLACK T, Smith D . The effect of bacteriophage T2 infection of the synthesis of transfer RNA in Escherichia coli. Virology. 1968; 36(2):212-22. DOI: 10.1016/0042-6822(68)90138-4. View

Dube S, Rudland P . Control of translation by T4 phage: altered binding of disfavoured messengers. Nature. 1970; 226(5248):820-3. DOI: 10.1038/226820a0. View

Waters L, NOVELLI G . A new change in leucine transfer RNA observed in Escherichia coli infected with bacteriophage T2. Proc Natl Acad Sci U S A. 1967; 57(4):979-85. PMC: 224643. DOI: 10.1073/pnas.57.4.979. View

10.

Hsu W, FOFT J, Weiss S . Effect of bacteriophage infection on the sulfur-labeling of sRNA. Proc Natl Acad Sci U S A. 1967; 58(5):2028-35. PMC: 223901. DOI: 10.1073/pnas.58.5.2028. View

11.

Wilhelm J, Haselkorn R . The chain growth rate of T4 lysozyme in vitro. Proc Natl Acad Sci U S A. 1970; 65(2):388-94. PMC: 282915. DOI: 10.1073/pnas.65.2.388. View

12.

Grollman A, Stewart M . Inhibition of the attachment of messenger ribonucleic acid to ribosomes. Proc Natl Acad Sci U S A. 1968; 61(2):719-25. PMC: 225219. DOI: 10.1073/pnas.61.2.719. View

13.

Steitz J, Dube S, Rudland P . Control of translation of T4 phage: altered ribosome binding at R17 initiation sites. Nature. 1970; 226(5248):824-7. DOI: 10.1038/226824a0. View

14.

Weiss S, Hsu W, FOFT J, Scherberg N . Transfer RNA coded by the T4 bacteriophage genome. Proc Natl Acad Sci U S A. 1968; 61(1):114-21. PMC: 285912. DOI: 10.1073/pnas.61.1.114. View

15.

Smolarsky M, Tal M . Novel method for measuring polyuridylic acid binding to ribosomes. Biochim Biophys Acta. 1970; 199(2):447-52. DOI: 10.1016/0005-2787(70)90087-0. View

16.

Hsu W, Weiss S . Selective translation of T4 template RNA by ribosomes from T4-infected Escherichia coli. Proc Natl Acad Sci U S A. 1969; 64(1):345-51. PMC: 286168. DOI: 10.1073/pnas.64.1.345. View

17.

Daniel V, Sarid S, LITTAUER U . Amino acid acceptor activity of bacteriophage T4 transfer RNA. FEBS Lett. 1968; 2(1):39-41. DOI: 10.1016/0014-5793(68)80095-x. View

18.

Sueoka N, KANO-SUEOKA T . A SPECIFIC MODIFICATION OF LEUCYL-SRNA OF ESCHERICHIA COLI AFTER PHAGE T2 INFECTION. Proc Natl Acad Sci U S A. 1964; 52:1535-40. PMC: 300482. DOI: 10.1073/pnas.52.6.1535. View

19.

Fraser D, JERREL E . The amino acid composition of T3 bacteriophage. J Biol Chem. 1953; 205(1):291-5. View

20.

Neidhardt F, Earhart C . Phage-induced appearance of a valyl sRNA synthetase activity in Escherichia coli. Cold Spring Harb Symp Quant Biol. 1966; 31:557-63. DOI: 10.1101/sqb.1966.031.01.072. View