New Directions in the Chemistry of Natural Products: the Organic Chemist As a Pathfinder for Biochemistry and Medicine

Overview

Journal Experientia

Specialty Science

Date 1971 Oct 15

PMID 4942649

Citations 3

Authors

B WITKOP

Affiliations

Soon will be listed here.

Citing Articles

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis.

Karkas M, Porco Jr J, Stephenson C Chem Rev. 2016; 116(17):9683-747.

PMID: 27120289 PMC: 5025835. DOI: 10.1021/acs.chemrev.5b00760.

Understanding the domino retro [3+2] cycloaddition/cyclization reaction of bicyclic isoxazolidines in the synthesis of spirocyclic alkaloids. A DFT study.

Layeb H, Nacereddine A, Djerourou A, Domingo L J Mol Model. 2014; 20(7):2347.

PMID: 25005002 DOI: 10.1007/s00894-014-2347-9.

[Synthesis of racemic pumiliotoxin C].

Habermehl G, Andres H Naturwissenschaften. 1975; 62(7):345-6.

PMID: 1196396 DOI: 10.1007/BF00608900.

References

Daly J, Axelrod J, WITKOP B . Dynamic aspects of enzymatic O-methylation and -demethylation of catechols in vitro and in vivo. J Biol Chem. 1960; 235:1155-9. View

Jerina D, Daly J, WITKOP B, ZALTZMAN-NIRENBERG P, UDENFRIEND S . The role of arene oxide-oxepin systems in the metabolism of aromatic substrates. 3. Formation of 1,2-naphthalene oxide from naphthalene by liver microsomes. J Am Chem Soc. 1968; 90(23):6525-7. DOI: 10.1021/ja01025a058. View

Kirk K, COHEN L . Participation of the anilino group in peptide bond cleavage. The use of t-butyl 3,5-dinitro-2-fluorocarbanilate as a peptide reagent. J Org Chem. 1969; 34(2):395-9. DOI: 10.1021/jo01254a029. View

Deshmukh K, Nimni M . Characterization of the aldehydes present on the cyanogen bromide peptides from mature rat skin collagen. Biochemistry. 1971; 10(9):1640-7. DOI: 10.1021/bi00785a022. View

Albuquerque E, Daly J, WITKOP B . Batrachotoxin: chemistry and pharmacology. Science. 1971; 172(3987):995-1002. DOI: 10.1126/science.172.3987.995. View

Daly J, Karle I, MYERS C, Tokuyama T, Waters J, WITKOP B . Histrionicotoxins: roentgen-ray analysis of the novel allenic and acetylenie spiroalkaloids isolated from a Colombian frog, Dendrobates histrionicus. Proc Natl Acad Sci U S A. 1971; 68(8):1870-5. PMC: 389311. DOI: 10.1073/pnas.68.8.1870. View

Yamamoto S, Bloch K . Studies on squalene epoxidase of rat liver. J Biol Chem. 1970; 245(7):1670-4. View

Daly J, Axelrod J, WITKOP B . Methylation and demethylation in relation to the in vitro metabolism of mescaline. Ann N Y Acad Sci. 1962; 96:37-43. DOI: 10.1111/j.1749-6632.1962.tb50099.x. View

Albuquerque E, Warnick J . Electrophysiological observations in normal and dystrophic chicken muscles. Science. 1971; 172(3989):1260-3. DOI: 10.1126/science.172.3989.1260. View

10.

Gally J, Edelman G . Somatic translocation of antibody genes. Nature. 1970; 227(5256):341-8. DOI: 10.1038/227341a0. View

11.

Axelrod J, SENOH S, WITKOP B . O-Methylation of catechol amines in vivo. J Biol Chem. 1958; 233(3):697-701. View

12.

Creveling C, Daly J, Tokuyama T, WITKOP B . Labile lipophilic derivatives of norepinephrine capable of crossing the blood-brain barrier. Experientia. 1969; 25(1):26-7. DOI: 10.1007/BF01903871. View

13.

Okamoto M, Longenecker Jr H, RIKER Jr W, Song S . Destruction of mammalian motor nerve terminals by black widow spider venom. Science. 1971; 172(3984):733-6. DOI: 10.1126/science.172.3984.733. View

14.

Reuben J . Substrate anchoring and the catalytic power of enzymes. Proc Natl Acad Sci U S A. 1971; 68(3):563-5. PMC: 388989. DOI: 10.1073/pnas.68.3.563. View

15.

Green N, WITKOP B . OXIDATION STUDIES OF INDOLES AND THE TERTIARY STRUCTURE OF PROTEINS. Trans N Y Acad Sci. 1964; 26:659-69. DOI: 10.1111/j.2164-0947.1964.tb01933.x. View

16.

Wieland T . Poisonous principles of mushrooms of the genus Amanita. Four-carbon amines acting on the central nervous system and cell-destroying cyclic peptides are produced. Science. 1968; 159(3818):946-52. DOI: 10.1126/science.159.3818.946. View

17.

Stein L, WISE C . Possible etiology of schizophrenia: progressive damage to the noradrenergic reward system by 6-hydroxydopamine. Science. 1971; 171(3975):1032-6. DOI: 10.1126/science.171.3975.1032. View

18.

Lindblad B, Lindstedt G, Lindstedt S . The mechanism of enzymic formation of homogentisate from p-hydroxyphenylpyruvate. J Am Chem Soc. 1970; 92(25):7446-9. DOI: 10.1021/ja00728a032. View

19.

Bruice T, Brown A, Harris D . On the concept of orbital steering in catalytic reactions. Proc Natl Acad Sci U S A. 1971; 68(3):658-61. PMC: 389011. DOI: 10.1073/pnas.68.3.658. View

20.

BARTHOLINI G, Kuruma I, Pletscher A . 3-O-methyldopa, a new precursor of dopamine. Nature. 1971; 230(5295):533-4. DOI: 10.1038/230533a0. View