Inhibition of Gastric Secretion by Atropine in Conscious Rats

Overview

Journal J Physiol

Specialty Physiology

Date 1971 Sep 1

PMID 4938464

Citations 14

Authors

I Johansson

L Lundell

S E SVENSSON

Affiliations

Soon will be listed here.

Abstract

1. The effect of atropine on acid and pepsin secretion, stimulated by feeding, vagus excitation or infusions of gastrin, histamine and methacholine, was studied in conscious rats provided with a Pavlov or a Heidenhain pouch.2. The acid and pepsin secretion in response to food was substantially suppressed by atropine in the Pavlov pouch.3. The strong stimulatory effect of 2-deoxy-D-glucose on acid and pepsin secretion in the Pavlov pouch was almost abolished by atropine.4. A plateau secretion of acid obtained by infusion of submaximal doses of hog gastrin II, was significantly inhibited by atropine in the Pavlov and the Heidenhain pouch.5. Methacholine-induced acid and pepsin secretion in the denervated Heidenhain pouch was nearly completely inhibited by atropine.6. A plateau secretion of acid evoked by infusing histamine in a near maximal dosage was inhibited by atropine to the same extent as the gastrin-induced secretion in the Pavlov pouch.7. The mode of action of atropine as a gastric secretory inhibitor is discussed.

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References

GREGORY R, TRACY H . The preparation and properties of gastrin. J Physiol. 1961; 156:523-43. PMC: 1359901. DOI: 10.1113/jphysiol.1961.sp006691. View

Hirschowitz B, Sachs G . Vagal gastric secretory stimulation by 2-deoxy-D-glucose. Am J Physiol. 1965; 209(3):452-60. DOI: 10.1152/ajplegacy.1965.209.3.452. View

ROSENGREN E, SVENSSON S . The role of the antrum and the vagus nerve in the formation of gastric mucosal histamine. J Physiol. 1969; 205(2):275-88. PMC: 1348601. DOI: 10.1113/jphysiol.1969.sp008964. View

KAHLSON G, ROSENGREN E, THUNBERG R . OBSERVATIONS ON THE INHIBITION OF HISTAMINE FORMATION. J Physiol. 1963; 169:467-86. PMC: 1368714. DOI: 10.1113/jphysiol.1963.sp007273. View

Grahn B, SVENSSON S . Evidence of gastrin-like activity in the rat's antrum. Experientia. 1970; 26(4):372. DOI: 10.1007/BF01896894. View

Konturek S . Effect of graded doses of pentagastrin, histamine and 2-deoxy-D-glucose on gastric secretion and motility in conscious rats. Scand J Gastroenterol. 1968; 3(6):572-6. View

Holzbauer M, Newport H . Quantitative estimation of 17alpha-hydroxypregn-4-ene-3,20-dione (17alphaOH-progesterone) in adrenal venous blood and adrenal glands. J Physiol. 1968; 198(1):91-102. PMC: 1365311. DOI: 10.1113/jphysiol.1968.sp008595. View

ALPHIN R, Lin T . Preparation of chronic denervated gastric pouches in the rat. Am J Physiol. 1959; 197:257-9. DOI: 10.1152/ajplegacy.1959.197.2.257. View

KAHLSON G, ROSENGREN E, SVENSSON S . Mode of action of a gastric-secretion antagonist. Br J Pharmacol Chemother. 1968; 33(3):493-500. PMC: 1570243. DOI: 10.1111/j.1476-5381.1968.tb00497.x. View

10.

Code C, HIGHTOWER Jr N, HALLENBECK G . Comparison of the effects of methantheline bromide (banthine) and atropine on the secretory responses of vagally innervated and vagally denervated gastric pouches. Gastroenterology. 1951; 19(2):254-64. View

11.

Hunt J . A method for estimating peptic activity in gastric contents. Biochem J. 1948; 42(1):104-9. PMC: 1258605. DOI: 10.1042/bj0420104. View

12.

Johansson I, Lundell L, SVENSSON S . Inhibition of gastrin-induced gastric secretion by atropine in innervated and denervated pouches in the conscious rat. J Physiol. 1971; 215(1):38P-39P. View

13.

Feinblatt J, Gelfand T, Smith G . Gastric acid response to 2-deoxy-D-glucose in chronic fistula rats. Proc Soc Exp Biol Med. 1966; 123(1):241-2. DOI: 10.3181/00379727-123-31455. View

14.

EMAS S . Gastric secretory responses to repeated intravenous infusions of histamine and gastrin in nonanesthetized and anesthetized gastric fistula cats. Gastroenterology. 1960; 39:771-82. View

15.

SVENSSON S . The secretory pattern of three stomach preparations in the rat. J Physiol. 1970; 207(2):329-50. PMC: 1348709. DOI: 10.1113/jphysiol.1970.sp009064. View

16.

Borg I, EMAS S . Effect of atropine on the gastric acid response to histamine and pentagastrin in conscious cats. Scand J Gastroenterol. 1970; 5(5):369-74. View

17.

HOLLANDER F, Janowitz H . Effect of atropine on histamine-stimulated gastric secretion in the dog. Am J Physiol. 1956; 186(3):373-6. DOI: 10.1152/ajplegacy.1956.186.3.373. View

18.

Edkins J . The chemical mechanism of gastric secretion. J Physiol. 1906; 34(1-2):133-44. PMC: 1465807. DOI: 10.1113/jphysiol.1906.sp001146. View

19.

KAHLSON G, ROSENGREN E, THUNBERG R . Accelerated mobilization and formation of histamine in the gastric mucosa evoked by vagal excitation. J Physiol. 1967; 190(3):455-63. PMC: 1365421. DOI: 10.1113/jphysiol.1967.sp008221. View

20.

Colin-Jones D, HIMSWORTH R . The location of the chemoreceptor controlling gastric acid secretion during hypoglycaemia. J Physiol. 1970; 206(2):397-409. PMC: 1348653. DOI: 10.1113/jphysiol.1970.sp009020. View