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Mitomycin C and Temperature Induction of Colicin B in the Absence of Deoxyribonucleic Acid Synthesis

Overview
Journal J Bacteriol
Publisher American Society for Microbiology
Specialty Microbiology
Date 1971 Sep 1
PMID 4937779
Citations 7
Authors
C Hausmann
R C CLOWES
Affiliations
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Abstract

An Escherichia coli K-12 strain and its mutant, temperature-sensitive in deoxyribonucleic acid (DNA) synthesis, were used as hosts for two different ColB factors (ColB3-K166 and ColB4-K98). Induction of either colicin occurred in both hosts in the presence of mitomycin C at 42 C. Induction of the temperature-sensitive colicinogenic hosts also occurred without mitomycin C at 42 C at which temperature no DNA synthesis was observed. Colicin synthesis was a nonlethal event in ColB4-K98(+) cultures, whereas in cultures of ColB3-K166(+) induction led to death of a large fraction of the population.

Citing Articles

Transcription regulation of colicin Ib synthesis.

Pugsley A Mol Gen Genet. 1981; 183(3):522-7.

PMID: 6460913 DOI: 10.1007/BF00268775.

Two major groups of colicin factors: their evolutionary significance.

Hardy K, Meynell G, Dowman J, Spratt B Mol Gen Genet. 1973; 125(3):217-30.

PMID: 4590272 DOI: 10.1007/BF00270744.

"Induction" of colicin factor E2-P9 by mitomycin C.

Hardy K, Meynell G J Bacteriol. 1972; 112(2):1007-9.

PMID: 4563964 PMC: 251514. DOI: 10.1128/jb.112.2.1007-1009.1972.

Studies on the regulation of colicin Ib synthesis: replication of the Col Ib-P9 plasmid during colicin induction.

Isaacson R, Konisky J Antimicrob Agents Chemother. 1974; 6(6):848-52.

PMID: 4451357 PMC: 444748. DOI: 10.1128/AAC.6.6.848.

Colicinogeny and related phenomena.

Hardy K Bacteriol Rev. 1975; 39(4):464-515.

PMID: 1108869 PMC: 408342. DOI: 10.1128/br.39.4.464-515.1975.

References
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