Vascular Lesions: Possible Pathogenetic Basis of the Generalized Shwartzman Reaction

Overview

Journal Science

Specialty Science

Date 1970 Nov 27

PMID 4920033

Citations 25

Authors

E Gaynor

C Bouvier

T H Spaet

Affiliations

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Abstract

Evidence of vascular injury was found in rabbits after a single small dose of endotoxin from Escherichia coli. Eighty percent of the treated animals developed circulating endothelial cells, leukopenia, and thrombocytopenia, and 50 percent had aortic endothelial lesions as determined by electron microscopy. Prior anticoagulation with heparin did not prevent this response. No control animals showed these abnormalities.

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