How Bacteriophage Chi Attacks Motile Bacteria

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1967 Jun 1

PMID 4918241

Citations 61

Authors

S Z Schade

J Adler

H RIS

Affiliations

Soon will be listed here.

Abstract

Bacteriophage chi attaches to the filament of a bacterial flagellum by means of a tail fiber, but the ultimate receptor site for the phage is located at the base of the bacterial flagellum. Here, the phage injects its deoxyribonucleic acid into the bacterium, leaving the empty phage attached at the base. It is suggested that chi slides along the filament of the flagellum to the base, owing to the movement of the flagellum. The role of motility would thus be to provide for rapid adsorption of the phage by guiding the phage to the adsorption sites at the bases of the flagella. Bacteria whose motility has been strongly inhibited by cold or anaerobic conditions still adsorb chi at the filaments and bases of flagella if a high multiplicity is used. This indicates that direct collisions with the bases may also be possible. Bacteria must be flagellated in order for chi to attach, but only a short flagellum, perhaps only the flagellar base, is necessary.

Citing Articles

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Genomic analysis of Salmonella bacteriophages revealed multiple endolysin ORFs and importance of ligand-binding site of receptor-binding protein.

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A hybrid receptor binding protein enables phage F341 infection of by binding to flagella and lipooligosaccharides.

Ostenfeld L, Sorensen A, Neve H, Vitt A, Klumpp J, Sorensen M Front Microbiol. 2024; 15:1358909.

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Phages on filaments: A genetic screen elucidates the complex interactions between Salmonella enterica flagellin and bacteriophage Chi.

Esteves N, Bigham D, Scharf B PLoS Pathog. 2023; 19(8):e1011537.

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The nut-and-bolt motion of a bacteriophage sliding along a bacterial flagellum: a complete hydrodynamics model.

Karabasov S, Zaitsev M, Nerukh D Sci Rep. 2023; 13(1):9077.

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