[Muscle Biopsy in Progressive External Ophthalmoplegia (author's Transl)]

Overview

Journal Klin Wochenschr

Specialty General Medicine

Date 1979 Aug 1

PMID 491500

Citations 5

Authors

D Pongratz

J Perwein

G Hubner

C Koppenwallner

K Toyka

K L Birnberger

Affiliations

Soon will be listed here.

Abstract

In skeletal muscle biopsies of nine patients with progressive external ophthalmoplegia of unknown origin "ragged red" fibers can be demonstrated. The occurrence of these abnormal fibers does not correlate with clinical muscle weakness, or additional signs of the ophthalmoplegia plus syndrome. Rarely, "ragged red" fibers are seen in other neuromuscular disorders but usually these are associated with various structural alterations. Numerous "ragged red" fibers in an otherwise normal muscle provide an essential criterion in establishing the diagnosis of the ophthalmoplegia plus syndrome.

Citing Articles

Progressive external ophthalmoplegia.

Hirano M, Pitceathly R Handb Clin Neurol. 2023; 194:9-21.

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Mitochondrial myopathies. Clinical, morphological and biochemical aspects.

Sengers R, STADHOUDERS A, Trijbels J Eur J Pediatr. 1984; 141(4):192-207.

PMID: 6329761 DOI: 10.1007/BF00572761.

Focal deficiency of cytochrome-c-oxidase in skeletal muscle of patients with progressive external ophthalmoplegia. Cytochemical-fine-structural study.

Muller-Hocker J, Pongratz D, Hubner G Virchows Arch A Pathol Anat Histopathol. 1983; 402(1):61-71.

PMID: 6318426 DOI: 10.1007/BF00695049.

Congestive heart failure due to mitochondrial cardiomyopathy in Kearns-Sayre syndrome.

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Variation in retinal changes and muscle pathology in mitochondriopathies.

Bosche J, Hammerstein W, Neuen-Jacob E, SCHOBER R Graefes Arch Clin Exp Ophthalmol. 1989; 227(6):578-83.

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