Mechanics of Frameshift Mutagenesis in Bacteriophage T4: Role of Chromosome Tips

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1970 Mar 1

PMID 4910850

Citations 8

Authors

D M Lindstrom

J W Drake

Affiliations

Soon will be listed here.

Abstract

In contrast to observations in bacteria and fungi, frameshift mutations in bacteriophage T4 do not arise during genetic recombination. Nascent mutants, captured in the heterozygous condition, exhibit properties which indicate that the new lesions are located at the extreme tips of the chromosomes, and are segregated by a combination of recombination and replication.

Citing Articles

A species barrier between bacteriophages T2 and T4: exclusion, join-copy and join-cut-copy recombination and mutagenesis in the dCTPase genes.

Gary T, Colowick N, Mosig G Genetics. 1998; 148(4):1461-73.

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The influence of neighboring base pairs upon base-pair substitution mutation rates.

KOCH R Proc Natl Acad Sci U S A. 1971; 68(4):773-6.

PMID: 5279518 PMC: 389040. DOI: 10.1073/pnas.68.4.773.

Reversion of frameshift mutations stimulated by lesions in early function genes of bacteriophage T4.

Bernstein H J Virol. 1971; 7(4):460-6.

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Ligase-defective bacteriophage T4. I. Effects on mutation rates.

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Inactivation of bacteriophage T4 by ethyl methanesulfonate: influence of host and viral genotypes.

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