Use of Chromosomal Translocations with in Situ DNA Hybridisation to Confirm Localisation of Human 5S Ribosomal RNA Genes

Overview

Journal J Med Genet

Specialty Genetics

Date 1979 Aug 1

PMID 490577

Citations 2

Authors

S J Fennell

S Malcolm

R Williamson

M A Ferguson-Smith

Affiliations

Soon will be listed here.

Abstract

Two cases of chromosomal translocations involving the long arm of chromosome 1 were investigated for 5S ribosomal gene localisation using in situ hybridisation. In the first family, there was an interstitial translocation of 1q25-32 to chromosome 5; the 5S genes remained on chromosome 1. In the second family, there was a translocation of 1q42-44 to chromosome 21q12; the 5S gene locus in this case was translocated. This shows that the 5S ribosomal genes are at position 1q42-44, confirming a previous assignment based on adenovirus-induced uncoiling and on a partial trisomy (Steffensen et al., 1977).

Citing Articles

Visualizing human 5S rDNA.

Pelliccia F, Gaddini L, Limongi M, Rocchi A Chromosome Res. 1997; 5(3):205-7.

PMID: 9246416 DOI: 10.1023/a:1018455200069.

Reduction of physical assignments to a standard lod table: chromosome 1.

Keats B, Morton N, Rao D Hum Genet. 1981; 56(3):353-9.

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