Article: The molecular origin of lambda prophage mRNA

Lambda-specific RNA extracted from lysogenic bacteria hybridizes specifically with fragments of lambda DNA containing 43 per cent GC (guanine plus cytosine). Therefore genes known to function in the prophage state (c(I) and rex) lie 0.38 +/- 0.08 fractional molecular length from the right end of the lambda DNA molecule, according to the compositional map of Skalka, Burgi, and Hershey.

Citing Articles

Hershey.

Stahl F Genetics. 1998; 149(1):1-6.

PMID: 9584081 PMC: 1460125. DOI: 10.1093/genetics/149.1.1.

A genetic assay for mRNA's of phage T4.

Jayaraman R, GOLDBERG E Proc Natl Acad Sci U S A. 1969; 64(1):198-204.

PMID: 5263003 PMC: 286147. DOI: 10.1073/pnas.64.1.198.

Comparisons of the distribution of nucleotides and common sequences in deoxyribonucleic acid from selected bacteriophages.

Skalka S, Hanson P J Virol. 1972; 9(4):583-93.

PMID: 4553679 PMC: 356342. DOI: 10.1128/JVI.9.4.583-593.1972.

References

1.

Gillespie D, Spiegelman S . A quantitative assay for DNA-RNA hybrids with DNA immobilized on a membrane. J Mol Biol. 1965; 12(3):829-42. DOI: 10.1016/s0022-2836(65)80331-x. View

2.

Zimmerman S, Sandeen D . The ribonuclease activity of crystallized pancreatic deoxyribonuclease. Anal Biochem. 1966; 14(2):269-77. DOI: 10.1016/0003-2697(66)90137-0. View

3.

Skalka A . Regional and temporal control of genetic transcription in phage lambda. Proc Natl Acad Sci U S A. 1966; 55(5):1190-5. PMC: 224298. DOI: 10.1073/pnas.55.5.1190. View

4.

Joyner A, Isaacs L, Echols H, Sly W . DNA replication and messenger RNA production after induction of wild-type lambda bacteriophage and lambda mutants. J Mol Biol. 1966; 19(1):174-86. DOI: 10.1016/s0022-2836(66)80059-1. View

5.

Taylor K, Hradecna Z, SZYBALSKI W . Asymmetric distribution of the transcribing regions on the complementary strands of coliphage lambda DNA. Proc Natl Acad Sci U S A. 1967; 57(6):1618-25. PMC: 224521. DOI: 10.1073/pnas.57.6.1618. View

6.

Skalka A, Butler B, Echols H . Genetic control of transcription during development of phage gamma. Proc Natl Acad Sci U S A. 1967; 58(2):576-83. PMC: 335674. DOI: 10.1073/pnas.58.2.576. View

7.

Howard B . Phage lambda mutants deficient in r-II exclusion. Science. 1967; 158(3808):1588-9. DOI: 10.1126/science.158.3808.1588. View

8.

Hogness D, DOERFLER W, Egan J, BLACK L . The position and orientation of genes in lambda and lambda dg DNA. Cold Spring Harb Symp Quant Biol. 1966; 31:129-38. DOI: 10.1101/sqb.1966.031.01.020. View

9.

Ravin V, Poluchina G . Mutants of phage lambda unable to exclude phage T4rII. Virology. 1968; 35(4):616-7. DOI: 10.1016/0042-6822(68)90292-4. View

10.

Kaiser A, Jacob F . Recombination between related temperate bacteriophages and the genetic control of immunity and prophage localization. Virology. 1957; 4(3):509-21. DOI: 10.1016/0042-6822(57)90083-1. View

11.

Burgi E . Changes in molecular weight of DNA accompanying mutations in phage. Proc Natl Acad Sci U S A. 1963; 49:151-5. PMC: 299767. DOI: 10.1073/pnas.49.2.151. View

12.

Sly W, Echols H, Adler J . CONTROL OF VIRAL MESSENGER RNA AFTER LAMBDA PHAGE INFECTION AND INDUCTION. Proc Natl Acad Sci U S A. 1965; 53:378-85. PMC: 219523. DOI: 10.1073/pnas.53.2.378. View

The Molecular Origin of Lambda Prophage MRNA