Identification of Closely Linked Loci Controlling Ultraviolet Sensitivity and Refractivity to Colicin E2 in Escherichia Coli

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1969 Jan 1

PMID 4884826

Citations 5

Authors

I B Holland

E J Threlfall

Affiliations

Soon will be listed here.

Abstract

Mutants (phenotypic symbol Ref-II) refractory to colicin E2 have been isolated in several strains of Escherichia coli K-12, and a refII locus has been mapped 1 to 2 min counter clockwise to thr. A small number of Ref-II mutants are also ultraviolet (UV)-sensitive and the uv(s) locus in one such strain has been mapped close to the refII locus near thr. The Ref-II mutation alone does not affect recombinant formation in F(-) strains, but the Ref-II, UV(s) strains behave in many respects like Rec(-) mutants, giving reduced recombination frequencies in crosses with male strains. It is suggested that the refII and uv(s) loci correspond to closely linked if not identical genes, concerned in some way in the activity of one or more deoxyribonucleases, and that the Ref-II, UV(s) mutants arise as the pleiotropic expression of a single gene or of a deletion or polar mutation affecting linked genes.

Citing Articles

Colicin tolerance induced by ampicillin or mutation to ampicillin resistance in a strain of Escherichia coli K-12.

Burman L, Nordstrom K J Bacteriol. 1971; 106(1):1-13.

PMID: 4994599 PMC: 248637. DOI: 10.1128/jb.106.1.1-13.1971.

Current linkage map of Escherichia coli.

Taylor A Bacteriol Rev. 1970; 34(2):155-75.

PMID: 4918631 PMC: 408314. DOI: 10.1128/br.34.2.155-175.1970.

Genetic studies of tolerance to colicin E2 in Escherichia coli K-12. II. Multiple mutations as a cause of the various phenotypic properties of cet minus mutants.

Buxton R, Holland I Mol Gen Genet. 1974; 131(2):159-71.

PMID: 4609202 DOI: 10.1007/BF00266151.

[Studies of mutations in glucuronate catabolism in Escherichia coli K12 (author's transl)].

Portalier R Mol Gen Genet. 1974; 131(1):31-46.

PMID: 4603847 DOI: 10.1007/BF00269385.

Recalibrated linkage map of Escherichia coli K-12.

Bachmann B, Low K, Taylor A Bacteriol Rev. 1976; 40(1):116-67.

PMID: 773363 PMC: 413944. DOI: 10.1128/br.40.1.116-167.1976.

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