The Development of Acquired Immunity to Tapeworms and Progress Towards Active Immunization, with Special Reference to Echinococcus Spp

Overview

Journal Bull World Health Organ

Specialty Public Health

Date 1968 Jan 1

PMID 4883063

Citations 5

Authors

M A Gemmell

E J Soulsby

Affiliations

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Abstract

An assessment is made of the present state of knowledge on acquired immune responses developed by the intermediate and definitive hosts to tapeworm infections. From this evaluation, some gaps in knowledge and some of the problems associated with the development of practical immunization techniques are described. The principal conclusion reached is that absolute resistance to the larval stage can be acquired and resistance to a number of cestode species can be artificially induced in a number of hosts. Thus, research directed towards isolation and characterization of the functional antigens may lead to the development of vaccines for use in public health programmes, such as for the control of echinococcosis, as well as for improving the present status of meat hygiene in regions where cysticercosis, for example, exists.

Citing Articles

Fact or hypothesis: concomitant immunity in taeniid cestode infections.

Lightowlers M Parasite Immunol. 2010; 32(8):582-9.

PMID: 20626813 PMC: 2913106. DOI: 10.1111/j.1365-3024.2010.01227.x.

The Styx field-trial. A study on the application of control measures against hydatid disease caused by Echinococcus granulosus.

Gemmell M Bull World Health Organ. 1968; 39(1):73-100.

PMID: 5303843 PMC: 2554384.

Antibody and cell-mediated immunity in rabbits infected with the larval stages of Taenia pisiformis.

Rickard M, Outteridge P Z Parasitenkd. 1974; 44(3):187-201.

PMID: 4432610 DOI: 10.1007/BF00328761.

The host response in secondary hydatidosis of mice. II. Cell mediated immunity.

Araj G, MATOSSIAN R, MALAKIAN A Z Parasitenkd. 1977; 52(1):31-8.

PMID: 888508 DOI: 10.1007/BF00380556.

Attempts to immunise rats and mice against infection with fasciola hepatica using antigens prepared from taenia hydatigena.

Rajasekariah G, Rickard M, Montague P, Mitchell G Z Parasitenkd. 1979; 58(2):175-80.

PMID: 433385 DOI: 10.1007/BF01951342.

References

Heyneman D . Studies on helminth immunity. IV. Rapid onset of resistance by the white mouse against a challenging infection with eggs of Hymenolepis nana (Cestoda: Hymenolepididae). J Immunol. 1962; 88:217-20. View

Gemmell M . Natural and acquired immunity factors inhibiting penetration of some hexacanth embryos through the intestinal barrier. Nature. 1962; 194:701-2. DOI: 10.1038/194701a0. View

Gemmell M . Species specific and cross-protective functional antigens of the tapeworm embryo. Nature. 1967; 213(5075):500-1. DOI: 10.1038/213500a0. View

Gemmell M . Natural and acquired immunity factors interfering with development during the rapid growth phase of Echinococcus granulosus in dogs. Immunology. 1962; 5:496-503. PMC: 1424078. View

Heyneman D . Studies on helminth immunity. II. Influence of Hymenolepis nana (Cestoda: Hymenolepididae) in dual infections with H. diminuta in white mice and rats. Exp Parasitol. 1962; 12:7-18. DOI: 10.1016/0014-4894(62)90062-0. View

Gemmell M . IMMUNOLOGICAL RESPONSES OF THE MAMMALIAN HOST AGAINST TAPEWORM INFECTIONS. 3. SPECIES SPECIFICITY OF HEXACANTH EMBRYOS IN PROTECTING SHEEP AGAINST TAENIA OVIS. Immunology. 1965; 8:281-90. PMC: 1423459. View

Norman L, KAGAN I . The maintenance of Echinococcus multilocularis in gerbils (Meriones unguiculatus) by intraperitoneal inoculation. J Parasitol. 1961; 47:870-4. View

Gemmell M . Immunological responses of the mammalian host against tapeworm infections. IV. Species specificity of hexacanth embryos in protecting sheep against Echinococcus granulosus. Immunology. 1966; 11(4):325-35. PMC: 1423843. View

LARSH Jr J . Host-parasite relationships in cestode infections, with emphasis on host resistance. J Parasitol. 1951; 37(4):343-52. View

10.

Mueller J . The laboratory propagation of Spirometra mansonoides as an experimental tool. V. Behavior of the sparganum in and out of the mouse host, and formation of immune precipitates. J Parasitol. 1961; 47:879-83. View

11.

Moya V, BLOOD B . [IMMUNOGENIC ACTIVITY OF A BIOLOGICAL PRODUCE TRIED AS A VACCINE AGAINST OVINE HYDATIDOSIS]. Bol Chil Parasitol. 1964; 19:7-10. View

12.

Gemmell M . IMMUNOLOGICAL RESPONSES OF THE MAMMALIAN HOST AGAINST TAPEWORM INFECTIONS. II. SPECIES SPECIFICITY OF HEXACANTH EMBRYOS IN PROTECTING RABBITS AGAINST TAENIA PISIFORMIS. Immunology. 1965; 8:270-80. PMC: 1423475. View

13.

URQUHART G . Epizootiological and experimental studies on bovine cysticercosis in East Africa. J Parasitol. 1961; 47:857-69. View

14.

Miller Jr H, Gardiner M . PASSIVE IMMUNITY TO INFECTION WITH A LARVAL TAPEWORM OF THE ALBINO RAT. Science. 1932; 75(1940):270. DOI: 10.1126/science.75.1940.270. View

15.

Heyneman D . HOST-PARASITE RESISTANCE PATTERNS--SOME IMPLICATIONS FROM EXPERIMENTAL STUDIES WITH HELMINTHS. Ann N Y Acad Sci. 1963; 113:114-29. DOI: 10.1111/j.1749-6632.1963.tb40662.x. View

16.

SCHWABE C, SCHINAZI L, Kilejian A . Host-parasite relationships in echinococcosis. II. Age resistance to secondary echinococcosis in the white mouse. Am J Trop Med Hyg. 1959; 8(1):29-36. View

17.

Silverman P . A technique for studying the in vitro effect of serum on activated taeniid hexacanth embryos. Nature. 1955; 176(4482):598-9. DOI: 10.1038/176598b0. View

18.

BAILEY W . Host-tissue reactions to initial and superimposed infections with Hymenolepis nana var. fraterna. J Parasitol. 1951; 37(5 1):440-4. View

19.

Heyneman D, WELSH J . Action of homologous antiserum in vitro against life cycle stages of Hymenolepis nana, the dwarf mouse tapeworm. Exp Parasitol. 1959; 8(2):119-28. DOI: 10.1016/0014-4894(59)90012-8. View

20.

Gemmell M . IMMUNOLOGICAL RESPONSES OF THE MAMMALIAN HOST AGAINST TAPEWORM INFECTIONS. I. SPECIES SPECIFICITY OF HEXACANTH EMBRYOS IN PROTECTING SHEEP AGAINST TAENIA HYDATIGENA. Immunology. 1964; 7:489-99. PMC: 1423419. View