Alpha 2.0
Login Register
» Articles » PMID: 4850594

Antibody to Hepatitis B Antigen in Haemophiliacs and Their Household Contacts

Overview
Journal J Clin Pathol
Specialty Pathology
Date 1974 Apr 1
PMID 4850594
Citations 4
Authors
C J Burrell
A C Parker
D M Ramsay
E Proudfoot
Affiliations
Soon will be listed here.
Abstract

The prevalence of antibody to hepatitis B antigen, detectable by radioimmunoassay, was found to be no higher among 58 long-term household contacts of multiply transfused haemophiliacs than among 100 randomly chosen blood donors. This suggested that such contacts do not have greater exposure to serum hepatitis virus than that occurring through natural means. Among those persons possessing antibody, the multiply transfused haemophiliacs showed a marked tendency for higher antibody titres than their contacts, implying differences in pathogenesis between infection acquired through multiple transfusion and infection acquired naturally.

Citing Articles

Prevalence of specific markers of viral hepatitis A and B among an Ethiopian population.

Gebreselassie L Bull World Health Organ. 1983; 61(6):991-6.

PMID: 6325033 PMC: 2536248.

Asymptomatic liver disease in haemophiliacs.

Mannucci P, Capitanio A, Del Ninno E, Colombo M, Pareti F, Ruggeri Z J Clin Pathol. 1975; 28(8):620-4.

PMID: 1184760 PMC: 475789. DOI: 10.1136/jcp.28.8.620.

Antibody to hepatitis B surface antigen in haemophiliacs on long-term therapy with Scottish factor VIII.

Burrell C, BLACK S, Ramsay D J Clin Pathol. 1978; 31(4):309-12.

PMID: 641208 PMC: 1145267. DOI: 10.1136/jcp.31.4.309.

Prevalence of antibody to hepatitits B surface antigen among staff in an Edinburgh hospital.

Burrell C, TONKIN R, Proudfoot E, Leadbetter G, Cowan P, LOCKERBIE L J Hyg (Lond). 1977; 78(1):57-68.

PMID: 264499 PMC: 2129744. DOI: 10.1017/s0022172400055935.

References
1.
Prince A, Burke K . Serum hepatitis antigen (SH): rapid detection by high voltage immunoelectroosmophoresis. Science. 1970; 169(3945):593-5. DOI: 10.1126/science.169.3945.593. View
2.
LANDER J, Alter H, Purcell R . Frequency of antibody to hepatitis-associated antigen as measured by a new radioimmunoassay technique. J Immunol. 1971; 106(5):1166-71. View
3.
Hollinger F, Vorndam V, Dreesman G . Assay of Australia antigen and antibody employing double-antibody and solid-phase radioimmunoassay techniques and comparison with the passive hemagglutination methods. J Immunol. 1971; 107(4):1099-111. View
4.
Almeida J, KULATILAKE A, Mackay D, SHACKMAN R, Chisholm G, MacGREGOR A . Possible airborne spread of serum-hepatitis virus within a haemodialysis unit. Lancet. 1971; 2(7729):849-50. DOI: 10.1016/s0140-6736(71)90223-6. View
5.
Heathcote J, Sherlock S . Spread of acute type-B hepatitis in London. Lancet. 1973; 1(7818):1468-70. DOI: 10.1016/s0140-6736(73)91809-6. View