Oral Contraceptives and Porphyria Cutanea Tarda

Overview

Journal Can Med Assoc J

Specialty General Medicine

Date 1974 May 4

PMID 4823112

Citations 4

Authors

A R Behm

W P Unger

Affiliations

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Abstract

The clinical and biochemical findings in two cases of porphyria cutanea tarda (PCT) are presented. The cases are unique in their early age of onset (24 and 22 years) and their apparent precipitation by low-dosage oral contraceptives.Review of the literature reveals these to be the two youngest patients with estrogen-induced PCT. Only one other case of PCT induced by low-dosage oral contraceptives has been reported. In most cases of PCT induced by estrogens, high dosages have been taken by patients over age 35.

Citing Articles

Porphyria cutanea tarda: comparison of cases precipitated by alcohol and estrogens.

HABERMAN H, Rosenberg F, Menon I Can Med Assoc J. 1975; 113(7):653-5.

PMID: 1181022 PMC: 1956714.

Contraceptive pill-induced porphyria cutanea tarda presenting with onycholysis of the finger nails.

Byrne J, Boss J, Dawber R Postgrad Med J. 1976; 52(610):535-8.

PMID: 981098 PMC: 2496458. DOI: 10.1136/pgmj.52.610.535.

Decreased liver cytochrome P-450 in rats caused by norethindrone or ethynyloestradiol.

White I, Muller-Eberhard U Biochem J. 1977; 166(1):57-64.

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Hormonal steroid contraceptives: a further review of adverse reactions.

McQueen E Drugs. 1978; 16(4):322-57.

PMID: 359313 DOI: 10.2165/00003495-197816040-00003.

References

COPEMAN P, CRIPPS D, Summerly R . Cutaneous hepatic porphyria and oestrogens. Br Med J. 1966; 1(5485):461-3. PMC: 1843617. DOI: 10.1136/bmj.1.5485.461. View

KOSKELO P, EISALO A, Toivonen I . Urinary excretion of porphyrin precursors and coproporphyrin in healthy females on oral contraceptives. Br Med J. 1966; 1(5488):652-4. PMC: 1843920. DOI: 10.1136/bmj.1.5488.652. View

ZIMMERMAN T, McMillin J, Watson C . Onset of manifestations of hepatic porphyria in relation to the influence of female sex hormones. Arch Intern Med. 1966; 118(3):229-40. View

Levere R . Stilbestrol-induced prophyria: increase in hepatic delta-aminolevulinic acid synthetase. Blood. 1966; 28(4):569-72. View

BAXTER D, Permowicz S, FLEISCHMAJER R . Variegate porphyria (mixed porphyria). Arch Dermatol. 1967; 96(1):98-100. DOI: 10.1001/archderm.96.1.98. View

VAIL Jr J . Porphyria cutanea tarda and estrogens. JAMA. 1967; 201(9):671-4. View

Burton J, Loudon N, Wilson A . Urinary coproporphyrin excretion and hepatic function in women taking oral contraceptives. Lancet. 1967; 2(7530):1326-7. DOI: 10.1016/s0140-6736(67)90912-9. View

De Feo C . Porphyria cutanea tarda. Arch Dermatol. 1968; 98(5):552-4. DOI: 10.1001/archderm.98.5.552. View

DOMONKOS A . Porphyria cutanea tarda induced by estrogen therapy. Arch Dermatol. 1970; 102(2):229. View

10.

Roenigk Jr H, Gottlob M . Estrogen-induced porphyria cutanea tarda. Report of three cases. Arch Dermatol. 1970; 102(3):260-6. View

11.

Stein K, Raque C, ZEIGERMAN J, Shrager J . Porphyria cutanea tarda induced by natural estrogens. A case report. Obstet Gynecol. 1971; 38(5):755-60. View

12.

McKenzie A, Acharya U . The oral contraceptive and variegate porphyria. Br J Dermatol. 1972; 86(5):453-7. DOI: 10.1111/j.1365-2133.1972.tb16096.x. View

13.

Christensen K, WITH T . Latent cutaneous porphyria, type PCT, in a Caucasian woman. Am J Med. 1972; 53(4):517-20. DOI: 10.1016/0002-9343(72)90148-9. View

14.

MUELLER M, Kappas A . ESTROGEN PHARMACOLOGY. I. THE INFLUENCE OF ESTRADIOL AND ESTRIOL ON HEPATIC DISPOSAL OF SULFOBROMOPHTHALEIN (BSP) IN MAN. J Clin Invest. 1964; 43:1905-14. PMC: 289635. DOI: 10.1172/JCI105064. View

15.

Dean G . ORAL CONTRACEPTIVES IN PORPHYRIA VARIEGATA. S Afr Med J. 1965; 39:278-80. View

16.

BECKER F . PORPHYRIA CUTANEA TARDA INDUCED BY ESTROGENS. Arch Dermatol. 1965; 92:252-6. DOI: 10.1001/archderm.92.3.252. View