Gating Currents of the Sodium Channels: Three Ways to Block Them

Overview

Journal Science

Specialty Science

Date 1974 Feb 22

PMID 4821243

Citations 50

Authors

F Bezanilla

C M ARMSTRONG

Affiliations

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Abstract

Preceding the opening of the sodium channels of axon membrane there is a small outward current, gating current, that is probably associated with the molecular rearrangements that open the channels. Gating current is reversibly blocked by three procedures that block the sodium current: (i) internal perfusion with zinc ions, (ii) inactivation of sodium conductance by brief depolarization, and (iii) prolonged depolarization.

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